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| | N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride Basic information |
| Product Name: | N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride | | Synonyms: | N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride;Verubulin hydrochloride;Azixa;MPC 6827 hydrochloride;N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine hydrochloride;EP-128495;Verubulin hydrochloride (MPC-6827 hydrochloride);MPC-6827,Microtubule/Tubulin,Verubulin,Verubulin hydrochloride,MPC 6827,inhibit,MPC6827,Inhibitor | | CAS: | 917369-31-4 | | MF: | C17H17N3O.HCl | | MW: | 315.79732 | | EINECS: | | | Product Categories: | | | Mol File: | 917369-31-4.mol |  |
| | N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride Chemical Properties |
| storage temp. | Desiccate at RT | | solubility | ≥10.55 mg/mL in DMSO; ≥28.1 mg/mL in EtOH; ≥5 mg/mL in H2O | | form | Powder | | color | White to light yellow |
| | N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride Usage And Synthesis |
| Uses | MPC 6827 Hydrochloride is a microtubule destabilizing agent which may be used in the treatment of patients with cancer. | | Biological Activity | mpc-6827 (azixa) is a small-molecule microtubule-destabilizing agent that binds to the same (or nearby) sites on β-tubulin as colchicine.[1]tubulin is a heterodimer consisting of an αand βmonomer, it can be covalently labeled with [3h] colchicine by near uv irradiation. most of the label appears in β tubulin. colchicine binds to tubulin with a stoichiometry of one and inhibits microtubule assembly substoichiometrically. colchicine binding to tubulin exhibits pseudoirreversible kinetics; it displays a fast step followed by a slow step involving conformational changes of both ligand and tubulin. the tubulin, in turn, promotes fluorescence characteristic of the tropolone moiety of colchicine. [2]mpc-6827 is a small-molecule microtubule-destabilizing agent that causes mitotic arrest and cell death. mpc-6827 interfere with microtubule dynamics, leading to arrest of dividing cells in the g2-m phase of the cell cycle, which eventually results in apoptotic cell death.[1] | | in vivo | mpc-6827 significantly inhibits the growth of various subcutaneously implanted tumor lines. mpc-6827 has also been shown to be a vascular-disrupting agent (vda) in a human ovarian carcinoma xenograft model. it also has shown synergism with carboplatin in a mouse xenograft model. furthermore, mpc-6827 has been shown to inhibit the growth of human glioblastoma tumor cell line (d-54) implanted intracranially in athymic nude mice. [1] | | storage | Desiccate at RT | | references | [1] tsimberidou am1, akerley w, schabel mc, etal. , phase i |
| | N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride Preparation Products And Raw materials |
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