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| 4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid Basic information |
Product Name: | 4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid | Synonyms: | 4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid;GIT 27;VGX-1027;2-(3-PHENYL-4,5-DIHYDROISOXAZOL-5-YL)ACETIC ACID;3-Phenyl-2-isoxazoline-5-acetic acid;VGX 1027 3-Phenyl-2-isoxazoline-5-acetic acid;(S,R)-3-Phenyl-4,5-dihydro-5-isoxasole acetic acid;2-Isoxazoline-5-acetic acid, 3-phenyl- | CAS: | 6501-72-0 | MF: | C11H11NO3 | MW: | 205.21 | EINECS: | | Product Categories: | Inhibitors | Mol File: | 6501-72-0.mol | |
| 4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid Chemical Properties |
Melting point | 157-158℃ | storage temp. | Sealed in dry,2-8°C | solubility | Soluble in DMSO (up to 30 mg/ml). | form | solid | color | White | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
Hazard Codes | Xn | Risk Statements | 22-43 | Safety Statements | 36/37 | HS Code | 2934.99.4400 |
| 4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid Usage And Synthesis |
Description | VGX-1027 (6501-72-0) is an immunomodulator that inhibits secretion of IL-1β, TNF-α, and IL-10 from murine macrophages stimulated with LPS and spares T cell function.1?Ameliorates the course of acute and chronic immunoinflammatory conditions such as carrageenan-induced pleurisy, LPS-induced lethality, and type II collagen-induced arthritis in mouse models.1?Prevents spontaneous and accelerated forms of autoimmune diabetes in a NOD mouse model.2?Modulates genes involved in LPS-induced Toll-like receptor 4 activation in a mouse Lupus model.3?Displays protective effects in particulate matter-induced acute lung injury by blocking TLR4 signaling.4 | Uses | 2-(3-Phenyl-4,5-dihydroisoxazol-5-yl)acetic Acid reduces the secretion of IL-1β, TNF-α and IL-10 from purified murine macrophages but not of T cells; and reduces the activation of NF-κB and p38 MAP kinase pathways along with up-regulation of ERK pathways. 2-(3-Phenyl-4,5-dihydroisoxazol-5-yl)acetic Acid inhibits proliferation of enterobacterial antigen-reactive CD4+CD25- T cells in vitro . | storage | Store at +4°C | References | 1) Stojanovic?et al.?(2007),?In vitro, ex vivo and in vivo immunopharmacological activities of the isooxazoline compound VGX-1027: modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models; Clin. Immunol.,?123?311
2) Stosic-Grujisic?et al.?(2007),?A potent immunomodulatory compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxazole acetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in NOD mice and inhibits the immunoinflammatory diabetes induced by multiple low doses of streptozotocin in CBA/H mice; J. Pharmacol. Exp. Ther.,?320?1038
3) Fagone?et al.?(2014),?VGX-1027 modulates genes involved in lipopolysaccharide-induced Toll-like receptor 4 activation and in a murine model of systemic lupus erythematosus; Immunology,?142?594
4) Xu?et al.?(2019),?Protective effects of VGX-1027 in PM2.5-induced airway inflammation and bronchial hyperresponsiveness; Eur. J, Pharmacol.,?842?373 |
| 4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid Preparation Products And Raw materials |
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