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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788 |
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jkinfo@jkchemical.com |
Products Intro: |
Product Name:Hydroxy(2-naphthyl)Methanephosphonic Acid CAS:132541-52-7 Package:250Mg,25Mg
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Company Name: |
Chemsky (shanghai) International Co.,Ltd
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021-50135380 |
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shchemsky@sina.com |
Products Intro: |
Product Name:Hydroxy(2-naphthyl)Methanephosphonic Acid;P-(Hydroxy-2-naphthalenylMethyl)phosphonic Acid; (Hydroxy-2-naphthalenylMethyl)phosphonic Acid; HNMPA CAS:132541-52-7 Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
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Company Name: |
Shanghai EFE Biological Technology Co., Ltd.
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Tel: |
021-65675885 18964387627 |
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info@efebio.com |
Products Intro: |
Product Name:Hydroxy(2-naphthyl)methanephosphonic Acid CAS:132541-52-7 Purity:98% (HPLC) Package:1mg;5mg;10mg
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| Hydroxy(2-naphthyl)Methanephosphonic Acid Basic information |
Product Name: | Hydroxy(2-naphthyl)Methanephosphonic Acid | Synonyms: | Hydroxy(2-naphthyl)Methanephosphonic Acid;P-(Hydroxy-2-naphthalenylMethyl)phosphonic Acid;Phosphonic acid, P-(hydroxy-2-naphthalenylmethyl)-;Inhibitor,HNMPA,serine autophosphorylation,tyrosine autophosphorylation,tyrosine kinase,Insulin Receptor,inhibit | CAS: | 132541-52-7 | MF: | C11H11O4P | MW: | 238.18 | EINECS: | | Product Categories: | Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Tyrosine Kinase Inhibitors;Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals, Tyrosine Kinase Inhibitors | Mol File: | 132541-52-7.mol | |
| Hydroxy(2-naphthyl)Methanephosphonic Acid Chemical Properties |
Melting point | >180oC(dec.) | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | solubility | DMSO, Methanol | form | White solid. | color | White to Off-White |
| Hydroxy(2-naphthyl)Methanephosphonic Acid Usage And Synthesis |
Description | HNMPA is a cell impermeable tyrosine kinase inhibitor that blocks receptor serine and tyrosine phosphorylation, including insulin receptor tyrosine kinase activity. It does not affect protein kinase C or cyclic AMP-dependent protein kinase activities. HNMPA inhibits the insulin-stimulated autophosphorylation of the 95-kDa β-subunit of the insulin receptor with an IC50 value of 200 μM in vitro. | Uses | A selective insulin receptor tyrosine kinase inhibitor | Uses | Insulin receptor tyrosine kinase (IRTK) inhibitor. | references | [1]. baltensperger k, lewis re, woon cw, et al. catalysis of serine and tyrosine autophosphorylation by the human insulin receptor. proc natl acad sci u s a. 1992 sep 1;89(17):7885-9. [2]. moon mj, kim hy, park s, et al. insulin contributes to fine-tuning of the pancreatic beta-cell response to glucagon-like peptide-1. mol cells. 2011 oct;32(4):389-95. |
| Hydroxy(2-naphthyl)Methanephosphonic Acid Preparation Products And Raw materials |
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