L-3,4-二羟基苯丙氨酸乙酯盐酸盐
| 中文名称 | L-3,4-二羟基苯丙氨酸乙酯盐酸盐 |
|---|---|
| 中文同义词 | L-3,4-二羟基苯丙氨酸乙酯盐酸盐;左旋多巴乙酯盐酸盐;化合物ETILEVODOPA HCL |
| 英文名称 | L-DOPA Ethyl Ester Hydrochloride |
| 英文同义词 | L-DOPA Ethyl Ester Hydrochloride;3,4-Dihydroxy-L-phenylalanine Ethyl Ester Hydrochloride;3-Hydroxy-L-tyrosine Ethyl Ester Hydrochloride;Levodopa Ethyl Ester Hydrochloride;O-Ethyl-DOPA Hydrochloride;3-hydroxy- L-Tyrosine ethyl ester, hydrochloride (1:1);Etilevodopa hydrochloride;Ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate hydrochloride |
| CAS号 | 39740-30-2 |
| 分子式 | C11H16ClNO4 |
| 分子量 | 261.7 |
| EINECS号 | |
| 相关类别 | Amino Acids & Derivatives;Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Amino Acids & Derivatives, Aromatics, Chiral Reagents, Pharmaceuticals, Intermediates & Fine Chemicals |
| Mol文件 | 39740-30-2.mol |
| 结构式 |  |
L-3,4-二羟基苯丙氨酸乙酯盐酸盐 性质
| 熔点 | 51-54°C |
|---|---|
| 储存条件 | Hygroscopic, Refrigerator, Under Inert Atmosphere |
| 溶解度 | 溶于甲醇、水 |
| 形态 | 固体 |
| 颜色 | 米白色 |
| 水溶解性 | Water: 125 mg/mL (477.65 mM) |
| 稳定性 | 吸湿性 |
Etilevodopa hydrochloride (L-Dopa ethyl ester hydrochloride) 是 Levodopa 的前药，在胃肠道中被非特异性酯酶快速水解为 Levodopa 和乙醇。Etilevodopa 用于帕金森病 (PD)的相关研究。Levodopa 是多巴胺的直接前体，有助于中枢神经系统的渗透和传递多巴胺。
Etilevodopa (L-Dopa ethyl ester) hydrochloride passes unchanged through the stomach to the duodenum, where it is rapidly hydrolyzed by local esterases to Levodopa and ethanol, and is subsequently absorbed into the blood stream as Levodopa.
Compared with standard Levodopa, Etilevodopa hydrochloride has greater solubility in the stomach, faster passage to the small intestine, and a shortened time to maximum Levodopa concentration.
用途
An active ingredient in preparations for the treatment of Parkinson鈥檚 disease.安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-116016A | L-3,4-二羟基苯丙氨酸乙酯盐酸盐 Etilevodopa hydrochloride | 39740-30-2 | 5mg | 350元 |
| 2024/08/19 | HY-116016A | L-3,4-二羟基苯丙氨酸乙酯盐酸盐 Etilevodopa hydrochloride | 39740-30-2 | 10mM * 1mLin Water | 390元 |