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Product Name:(E)-C-HDMAPP (ammonium salt)
CAS:933030-60-5
Purity:>98% Package:1mg;10mg;50mg;100mg;
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Product Name:(E)-C-HDMAPP (ammonium salt)
CAS:933030-60-5
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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Product Name:(E)-C-HDMAPP (ammonium salt)
CAS:933030-60-5
Purity:98% Package:1mg; 500ug; 5mg; 10mg Remarks:Medbio
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Product Name:(E)-C-HDMAPP (ammonium salt) Exclusive
CAS:933030-60-5
Purity:95% Package:500μg;1mg;5mg
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TargetMol Chemicals Inc.
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Product Name:(E)-C-HDMAPP (ammonium salt)
CAS:933030-60-5
Purity:详情请点击官网 Package:1 mg
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| | (E)-C-HDMAPP (ammonium salt) Basic information |
| Product Name: | (E)-C-HDMAPP (ammonium salt) | | Synonyms: | (E)-C-HDMAPP (ammonium salt);triazanium:[(E)-5-hydroxy-4-methylpent-3-enyl]-phosphonatooxyphosphinate;(E)-C-HDMAPP (ammonium salt) Exclusive | | CAS: | 933030-60-5 | | MF: | C6H17NO7P2 | | MW: | 277.15 | | EINECS: | | | Product Categories: | | | Mol File: | 933030-60-5.mol |  |
| | (E)-C-HDMAPP (ammonium salt) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | PBS (pH 7.2): 10 mg/ml | | form | A crystalline solid |
| | (E)-C-HDMAPP (ammonium salt) Usage And Synthesis |
| Description | Synthetic and natural alkyl phosphates, also known as phosphoantigens, stimulate the proliferation of γδ-T lymphocytes.1 Isopentenyl pyrophosphate, and related derivatives including (E)-hydroxy-dimethyl-allyl pyrophosphate ((E)-HDMAPP), are particularly effective activators of γδ-T cells.2,3 (E)-C-HDMAPP is the pyrophosphonate form of (E)-HDMAPP. The pyrophosphonate moiety in (E)-C-HDMAPP is much less susceptible to chemical or enzymatic hydrolysis than its pyrophosphate counterpart. As a result, (E)-C-HDMAPP is much more stable in solution and in vascular circulation.4 (E)-C-HDMAPP possesses comparable activity to (E)-HDMAPP, which is the most potent of the isoprenoid phosphoantigens. (E)-C-HDMAPP stimulates the synthesis of tumor necrosis factor (TNF-α) by γδ-T lymphocytes with an IC50 value of 0.91 nM.4 (E)-C-HDMAPP also significantly increases the number of circulating γδ-T cells in vivo, in cynomolgus monkeys.4 | | Uses | (E)-C-HDMAPP (Ammonium Salt) is a useful research chemical compound used in the preparation of phosphoantigen salts of organic bases and methods for their crystallization. | | References | 1. Tanaka, Y., Sano, S., Nieves, E., et al. Nonpeptide ligands for human γδ T cells Proc. Natl. Acad. Sci. USA 91(17),8175-8179(1994).
2. Poupot, M., and Fournié, J.J. Non-peptide antigens activating human Vγ9/Vδ2 T lymphocytes Immunol. Lett. 95(2),129-138(2004).
3. Tanaka, Y., Morita, C.T., Tanaka, Y., et al. Natural and synthetic non-peptide antigens recognized by human γδ T cells Nature 375(6527),155-158(1995).
4. Bo?dec, A., Sicard, H., Dessolin, J., et al. Synthesis and biological activity of phosphonate analogues and geometric isomers of the highly potent phosphoantigen (E)-1-hydroxy-2-methylbut-2-enyl 4-diphosphate J. Med. Chem. 51(6),1747-1754(2008). |
| | (E)-C-HDMAPP (ammonium salt) Preparation Products And Raw materials |
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