1-Oleoyl Lysophosphatidic Acid
| 中文名称 | 1-Oleoyl Lysophosphatidic Acid |
|---|---|
| 中文同义词 | |
| 英文名称 | 1-Oleoyl Lysophosphatidic Acid |
| 英文同义词 | 1-Oleoyl Lysophosphatidic Acid Exclusive;9-Octadecenoic acid (9Z)-, (2R)-2-hydroxy-3-(phosphonooxy)propyl ester;WRGQSWVCFNIUNZ-GDCKJWNLSA-N |
| CAS号 | 65528-98-5 |
| 分子式 | C21H41O7P |
| 分子量 | 436.52 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 65528-98-5.mol |
| 结构式 |  |
1-Oleoyl Lysophosphatidic Acid 性质
| 沸点 | 581.5±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.103±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMF：2mg/mL； DMSO：2.5mg/mL；乙醇：25mg/mL； PBS（pH 7.2）：3 mg/mL |
| 形态 | 液体 |
| 酸度系数(pKa) | 1.82±0.10(Predicted) |
| 颜色 | 无色至浅黄 |
1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) 是一种丰富的溶血磷脂酸种类，由于其对 LPA 受体 (LPA receptors) 的强亲和力，具有很高的生物活性。1-Oleoyl lysophosphatidic acid 在大多数实验室中常用作 LPA 受体激活的试剂。1-Oleoyl lysophosphatidic acid 可增加 SRE 驱动的 β-galactosidase 的活性。
1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) (0.4-2 μg; i.c.v.; 9-week-old male Wistar rats) induces anxiety-like responses in the elevated plus maze (EPM) under novelty conditions.
| Animal Model: | 9-week-old male Wistar rats |
| Dosage: | 0.4-2 μg |
| Administration: | I.c.v. |
| Result: | Reduced open arm exploration under novelty conditions and had no effect under habituated conditions in the EPM. |