| Company Name: |
Beijing Jin Ming Biotechnology Co., Ltd.
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| Tel: |
010-60605840 15801484223; |
| Email: |
psaitong@jm-bio.com |
| Products Intro: |
Product Name:5-((5-(4-Fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione
CAS:328960-84-5
Purity:95% Package:1g
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| Company Name: |
Nanjing Tengyi Biotechnology Co., Ltd
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| Tel: |
025-58851786 17714337195 |
| Email: |
sales@tybiochem.com |
| Products Intro: |
Product Name:2,4-Thiazolidinedione, 5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-
CAS:328960-84-5
Purity:95+% Package:1g;5g
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| Company Name: |
Carbosynth
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| Tel: |
+86 512 6260 5585 |
| Email: |
sales@carbosynth.com |
| Products Intro: |
Product Name:CAY10505
CAS:328960-84-5
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| Company Name: |
Cayman Chemical Company
|
| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:CAY10505
CAS:328960-84-5
Package:>=98% Remarks:10009078
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| | CAY10505 Basic information |
| Product Name: | CAY10505 | | Synonyms: | (5E)-5-{[5-(4-fluorophenyl)furan-2-yl]methylidene}-1,3-thiazolidine-2,4-dione;5-((5-(4-Fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione;2,4-Thiazolidinedione, 5-[[5-(4-fluorophenyl)-2-furanyl]methylene]- | | CAS: | 328960-84-5 | | MF: | C14H8FNO3S | | MW: | 289.28 | | EINECS: | | | Product Categories: | | | Mol File: | 328960-84-5.mol |  |
| | CAY10505 Chemical Properties |
| density | 1.466±0.06 g/cm3(Predicted) | | solubility | DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.15 mg/ml | | form | A crystalline solid | | pka | 6.21±0.20(Predicted) |
| | CAY10505 Usage And Synthesis |
| Description | Phosphoinositide 3-kinase γ (PI3Kγ), expressed primarily in hematopoietic cells, plays several important roles in immunity. CAY10505 is a potent inhibitor of PI3K, selectively inhibiting the γ isoform (IC50 = 30 nM) better than the α, β, and δ isoforms (IC50 = 0.94, 20, and 20 μM, respectively).1 Tested against a panel of 80 other kinases, CAY10505 significantly inhibits only the unrelated casein kinase 2 (CK2, IC50 = 20 nM). It also inhibits the phosphorylation of the PI3K substrate PKB/Akt in mouse macrophages (IC50 = 228 nM).1 Oral administration of CAY10505 reduces neutrophil recruitment in mice to an extent that is comparable to that observed in PI3Kγ-deficient mice.1 | | References | 1. Pomel, V., Klicic, J., Covini, D., et al. Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase γ J. Med. Chem. 49(13),3857-3871(2006). |
| | CAY10505 Preparation Products And Raw materials |
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