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| | SB 203580 (hydrochloride) Basic information |
| Product Name: | SB 203580 (hydrochloride) | | Synonyms: | RWJ 64809 hydrochloride;RWJ 64809 HYDROCHLORIDE;SB203580 HYDROCHLORIDE;SB-203580 HYDROCHLORIDE;SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem;Adezmapimod (hydrochloride);Adezmapimod (SB-203580) hydrochloride | | CAS: | 869185-85-3 | | MF: | C21H17ClFN3OS | | MW: | 413.9 | | EINECS: | | | Product Categories: | | | Mol File: | 869185-85-3.mol |  |
| | SB 203580 (hydrochloride) Chemical Properties |
| storage temp. | -20C | | solubility | insoluble in EtOH; insoluble in H2O; ≥20.7 mg/mL in DMSO | | form | Bright yellow solid | | color | Light yellow to yellow | | Water Solubility | Soluble to 25 mM in water | | Stability: | Hygroscopic |
| | SB 203580 (hydrochloride) Usage And Synthesis |
| Uses | SB 203580 Hydrochloride is a protein kinase inhibitor. | | General Description | A water-soluble form of the potent MAP kinase inhibitor SB 203580 (Cat. No. 559389). | | Biological Activity | sb203580 hcl is a specific inhibitor of p38-mapks with ic50 value of 0.6 μm [1].sb203580 is an inhibitor of p38-mapkα and p38-mapkβ. in neonatal myocytes, sb203580 prevented p38-mapk from activating mapkapk2 with ic50 value of 70 nm. it also significantly suppressed mapkapk2 activation in by il-1, osmotic stress or arsenite in kb cells. in neonatal rat ventricular myocytes, sb203580 inhibited jnk activity of activating c-jun with ic50 value of 3-10 μm. besides that, sb203580 affected the phosphorylation of small heat shock proteins caused by mapkapk2. it inhibited the il-1-, chemical- or osmotic stress-stimulated hsp27 phosphorylation with ic50 value of < 1μm in kb cells [1, 2]. | | Biochem/physiol Actions | Cell permeable: yes | | storage | Store at -20°C | | references | [1] cuenda a, rouse j, doza y n, et al. sb 203580 is a specific inhibitor of a map kinase homologue which is stimulated by cellular stresses and interleukin-1. febs letters, 1995, 364(2): 229-233.
[2] clerk a, sugden p h. the p38-mapk inhibitor, sb203580, inhibits cardiac stress-activated protein kinases/c-jun n-terminal kinases (sapks/jnks). febs letters, 1998, 426(1): 93-96. |
| | SB 203580 (hydrochloride) Preparation Products And Raw materials |
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