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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
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Product Name:Stearoyl Serotonin
CAS:67964-87-8
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
MedBioPharmaceutical Technology Inc
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| Tel: |
021-69568360 18916172912 |
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order@med-bio.cn |
| Products Intro: |
Product Name:Stearoyl Serotonin
CAS:67964-87-8
Purity:98% Package:5mg; 10mg; 1mg; 25mg Remarks:Medbio
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| Company Name: |
ApexBio Technology
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+ 1-832-696-8203 |
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sales@apexbt.com |
| Products Intro: |
Product Name:Stearoyl Serotonin
CAS:67964-87-8
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| Company Name: |
Cayman Chemical Company
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| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:Stearoyl Serotonin
CAS:67964-87-8
Package:>=98% Remarks:9000631
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| | Stearoyl Serotonin Basic information |
| Product Name: | Stearoyl Serotonin | | Synonyms: | Stearoyl Serotonin;Stearoyl Serotonin Exclusive;N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]octadecanamide;N-(2-(5-Hydroxy-1H-indol-3-yl)ethyl)stearamide;Octadecanamide, N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]- | | CAS: | 67964-87-8 | | MF: | C28H46N2O2 | | MW: | 442.68 | | EINECS: | | | Product Categories: | | | Mol File: | 67964-87-8.mol |  |
| | Stearoyl Serotonin Chemical Properties |
| Boiling point | 652.4±45.0 °C(Predicted) | | density | 1.014±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≤2.5mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide | | form | crystalline solid | | pka | 10.08±0.40(Predicted) |
| | Stearoyl Serotonin Usage And Synthesis |
| Definition | ChEBI: N-stearoylserotonin is an N-acylserotonin obtained by formal condensation of the carboxy group of stearic acid with the primary amino group of serotonin. It has been found in the jejunum and ileum of pigs and mice. It is functionally related to an octadecanoic acid. | | Biological Activity | stearoyl serotonin is a trpv1 antagonist with ic50 value of 0.76 μm for human trpv1 [1].the transient receptor potential vanilloid-type 1 (trpv1) channel is a nonselective cation channel that may be activated by a variety of exogenous and endogenous physical and chemical stimuli. trpv1 is decreased in the injured nerve fibers but increased in those proximal to the site damage. trpv1 is a potential new target for the development of analgesic and anti-inflammatory drugs [1].stearoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin. arachidonoyl serotonin is a dual antagonist of trpv1 and fatty acid amide hydrolase (faah) with ic50 values of 0.27 and 8 μm, respectively. arachidonoyl serotonin was highly effective against both acute and chronic peripheral pain [1][2]. in trpv1 and faah assays, stearoyl serotonin inhibited anandamide hydrolysis mediated by faah and capsaicin-induced intracellular ca2+ elevation in hek293 cells overexpressing the human recombinant trpv1 receptor with ic50 values of > 50 μm and 0.76 μm, respectively. however, the effects of replacing the arachidonoyl portion with the saturated 18-carbon stearoyl moiety had not been studied [1]. | | references | [1]. ortar g, cascio mg, de petrocellis l, et al. new n-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain. j med chem. 2007 dec 27;50(26):6554-69.
[2]. maione s, de petrocellis l, de novellis v, et al. analgesic actions of n-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid trpv1 receptors. br j pharmacol. 2007 mar;150(6):766-81. |
| | Stearoyl Serotonin Preparation Products And Raw materials |
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