| Company Name: |
BOC Sciences
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16314854226 |
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Product Name:GSK3β Inhibitor XVIII
CAS:1139875-74-3
Purity:98% Package:1G;10G;100G Remarks:GSK3β inhibitor XVIII is a cell-permeable, potent and selective inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = 64 nM).
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
| Products Intro: |
Product Name:GSK3β Inhibitor XVIII
CAS:1139875-74-3
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Jinan Jiuli Biotechnology Co. , Ltd.
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| Tel: |
15865264761 |
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486064515@qq.com |
| Products Intro: |
Product Name:GSK-3β inhibitor 8
CAS:1139875-74-3
Purity:98% Package:500mg；1g；5g
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| | GSK-3β Inhibitor XVIII Basic information |
| Product Name: | GSK-3β Inhibitor XVIII | | Synonyms: | GSK-3β Inhibitor XVIII;GSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem;GSK3β-IN-1a;GSK3β Inhibitor XVIII;Methanone, [2-chloro-4-[[4-(2-thienyl)-2-pyrimidinyl]amino]phenyl](4-methyl-1-piperazinyl)-;2-chloro-4-[[4-(2-thienyl)-2-pyrimidinyl]amino]phenyl](4-methyl-1-piperazinyl)-,methanone;GSK-3β inhibitor 8 | | CAS: | 1139875-74-3 | | MF: | C20H20ClN5OS | | MW: | 413.92 | | EINECS: | | | Product Categories: | | | Mol File: | 1139875-74-3.mol |  |
| | GSK-3β Inhibitor XVIII Chemical Properties |
| Boiling point | 632.3±65.0 °C(Predicted) | | density | 1.358±0.06 g/cm3(Predicted) | | storage temp. | +2C to +8C | | solubility | DMSO: soluble | | pka | 6?+-.0.10(Predicted) | | form | White solid | | color | White to off-white |
| | GSK-3β Inhibitor XVIII Usage And Synthesis |
| Description | GSK3β inhibitor XVIII is an inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = 64 nM). It induces expression of a luciferase reporter in HEK293 cells expressing wild-type Wnt (EC50 = ~1.25 μM) but not in cells expressing a β-catenin/TCF binding site-mutant Wnt. GSK3β inhibitor XVIII increases β-catenin accumulation in the nucleus of HEK293 cells. It induces proliferation of R7T1 β-cells (EC50 = 1,143 nM), an effect that can be blocked by the COX and Wnt signaling inhibitor sulindac , and rat primary β-cells. | | Uses | GSK-3β inhibitor 8, a thiophenacil derivative, is an effective and selective inhibitor of GSK-3β (IC50=64 nM). GSK-3β inhibitor 8 negatively regulated Wnt signaling pathway and stimulated β cell proliferation[1][2]. | | IC 50 | GSK-3β: 64 nM (IC50) | | References | [1] Wang W, et al. Identification of small-molecule inducers of pancreatic beta-cell expansion. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1427-32. DOI:10.1073/pnas.0811848106 |
| | GSK-3β Inhibitor XVIII Preparation Products And Raw materials |
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