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| | 4-((4-ethylpiperazin-1-yl)Methyl)-3-(trifluoroMethyl)aniline Basic information |
| | 4-((4-ethylpiperazin-1-yl)Methyl)-3-(trifluoroMethyl)aniline Chemical Properties |
| Boiling point | 344.9±42.0 °C(Predicted) | | density | 1.195±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | soluble in Dichloromethane; | | form | Solid | | pka | 7.76±0.10(Predicted) | | color | Yellow |
| | 4-((4-ethylpiperazin-1-yl)Methyl)-3-(trifluoroMethyl)aniline Usage And Synthesis |
| Uses | 4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)-benzenamine is one of the key reactants with N-[1-(4-Aminophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide used in the synthesis of a pyrrolo[3,2-c]pyridine derivative [N-[1-[4-[[[[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide (I)], an anticancer diarylurea derivative with multiple-kinase inhibitory effect; Also, it is an intermediate used in the synthesis of N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N''-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea (E926495), which is an inhibitor of RET, FLT3, KDR, c-Abl and c-Kit. Also, it prevent the growth of human thyroid cancer cells. |
| | 4-((4-ethylpiperazin-1-yl)Methyl)-3-(trifluoroMethyl)aniline Preparation Products And Raw materials |
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