7H-Pyrrolo[3,2-f]quinazoline-1,3-diaMine, N3-cyclopropyl-7-[[4-(1-Methylethyl)phenyl]Methyl]-, (Hydrochloride) (1:2) manufacturers
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| | 7H-Pyrrolo[3,2-f]quinazoline-1,3-diaMine, N3-cyclopropyl-7-[[4-(1-Methylethyl)phenyl]Methyl]-, (Hydrochloride) (1:2) Basic information |
| Product Name: | 7H-Pyrrolo[3,2-f]quinazoline-1,3-diaMine, N3-cyclopropyl-7-[[4-(1-Methylethyl)phenyl]Methyl]-, (Hydrochloride) (1:2) | | Synonyms: | 7H-Pyrrolo[3,2-f]quinazoline-1,3-diaMine, N3-cyclopropyl-7-[[4-(1-Methylethyl)phenyl]Methyl]-, (Hydrochloride) (1:2);SCH 79797 (hydrochloride);infarct,SCH79797 dihydrochloride,SCH-79797 dihydrochloride,SCH-79797,SCH79797,Inhibitor,inhibit,Nonpeptide,thrombin,wortmannin,SCH 79797,antiproliferative,platelets,Protease Activated Receptor (PAR),pro-apoptotic,thrombosis,Thrombin receptors,PAR1,cardioprotection,Apoptosis;N3-Cyclopropyl-7-(4-isopropylbenzyl)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride | | CAS: | 1216720-69-2 | | MF: | C23H26ClN5 | | MW: | 407.95 | | EINECS: | | | Product Categories: | Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals | | Mol File: | 1216720-69-2.mol | ![7H-Pyrrolo[3,2-f]quinazoline-1,3-diaMine, N3-cyclopropyl-7-[[4-(1-Methylethyl)phenyl]Methyl]-, (Hydrochloride) (1:2) Structure](CAS/GIF/1216720-69-2.gif) |
| | 7H-Pyrrolo[3,2-f]quinazoline-1,3-diaMine, N3-cyclopropyl-7-[[4-(1-Methylethyl)phenyl]Methyl]-, (Hydrochloride) (1:2) Chemical Properties |
| storage temp. | Store at 2-8°C, protect from light | | solubility | Soluble to 25 mM in ethanol and to 50 mM in DMSO | | form | Powder | | color | White to yellow |
| | 7H-Pyrrolo[3,2-f]quinazoline-1,3-diaMine, N3-cyclopropyl-7-[[4-(1-Methylethyl)phenyl]Methyl]-, (Hydrochloride) (1:2) Usage And Synthesis |
| Description | SCH 79797 is a non-peptide antagonist of proteinase-activated receptor 1 (PAR1). It blocks binding of the high affinity thrombin receptor-activating peptide (haTRAP) (IC50 = 70 nM) as well as platelet aggregation induced by either haTRAP or α-thrombin (IC50 = 0.3 and 3 μM, respectively). SCH 79797 has no activity against PAR2, PAR4, or other receptors involved in platelet activation. It also blocks PAR1 activation on vascular smooth muscle cells and endothelial cells. | | Uses | SCH 79797 Dihydrochloride is a selective PAR1 antagonist. | | Uses | N3-Cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine Dihydrochloride is a selective PAR1 antagonist which was shown to limit myocardial ischemia/reperfusion injury in rat hearts. | | storage | Desiccate at RT |
| | 7H-Pyrrolo[3,2-f]quinazoline-1,3-diaMine, N3-cyclopropyl-7-[[4-(1-Methylethyl)phenyl]Methyl]-, (Hydrochloride) (1:2) Preparation Products And Raw materials |
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