- Otenaproxesul
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- $34.00 / 2mg
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2024-11-19
- CAS:1226895-20-0
- Min. Order:
- Purity: 99.23%
- Supply Ability: 10g
- ATB 346
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- $1.00 / 1KG
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2020-01-03
- CAS:1226895-20-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 200kg
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| | ATB 346 Basic information |
| Product Name: | ATB 346 | | Synonyms: | ATB 346;4-CARBAMOTHIOYLPHENYL 2-(6-METHOXYNAPHTHALEN-2-YL)PROPANOATE;ABT-346;6-Methoxy-alpha-methyl-2-naphthaleneacetic acid 4-(aminothioxomethyl)phenyl ester;6-Methoxy-alpha-methyl-2-naphthaleneacetic acid 4-(aminothioxomethyl)phenyl ester ATB 346;ATB 346 6-Methoxy-alpha-methyl-2-naphthaleneacetic acid 4-(aminothioxomethyl)phenyl ester;ATB-346, >=98%;ATB 346,1226895-20-0 | | CAS: | 1226895-20-0 | | MF: | C21H19NO3S | | MW: | 365.45 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 1226895-20-0.mol |  |
| | ATB 346 Chemical Properties |
| Boiling point | 561.4±60.0 °C(Predicted) | | density | 1.261±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | insoluble in EtOH; insoluble in H2O; ≥18.27 mg/mL in DMSO | | form | solid | | pka | 12.37±0.29(Predicted) | | color | Light yellow to yellow |
| | ATB 346 Usage And Synthesis |
| Description | ATB-346 is a non-steroidal anti-inflammatory drug (NSAID) that releases hydrogen sulfide (H2S) and a derivative of naproxen . It inhibits the proliferation of, and induces apoptosis in, A375 melanoma cells when used at a concentration of 100 μM. ATB-346 decreases prostaglandin E2 (PGE2) production in inflammatory exudates, reduces paw edema, and increases plasma levels of sulfide in a mouse model of zymosan-induced arthritis. It reduces the size of acetic acid-induced gastric ulcers in mice when administered at a dose of 60 μmol/kg. ATB-346 (30 μmol/kg) improves motor function in a mouse model of spinal cord injury. | | references | [1] wallace j l, caliendo g, santagada v, et al. markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (atb-346). british journal of pharmacology, 2010, 159(6): 1236-1246. |
| | ATB 346 Preparation Products And Raw materials |
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