CBB 1007

CBB 1007 Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:CBB1007
CAS:1379573-92-8
Purity:98.00% Package:100 mg;500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel: +86-057181025280; +8617767106207
Email: sales@molcore.com
Products Intro: Product Name:CBB1007
CAS:1379573-92-8
Purity:NLT 98% Remarks:MC816919
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Email: sales@amadischem.com
Products Intro: Product Name:CBB1007
CAS:1379573-92-8
Purity:0.97 Package:mgs,gs,kgs Remarks:A922156
Company Name: MedChemexpress LLC  
Tel: 021-58955995
Email: sales@medchemexpress.cn
Products Intro: Product Name:CBB1007
CAS:1379573-92-8
Purity:>98% Package:1550RMB/2mg
Company Name: LETOPHARM LIMITED  
Tel: +86-21-5821 5861
Email: sales@letopharm.com
Products Intro: Product Name:CBB1007
CAS:1379573-92-8
CBB 1007 Basic information
Product Name:CBB 1007
Synonyms:CBB 1007;CS-1737;SCHEMBL16273312;Benzoic acid, 3-[[4-[4-(aminoiminomethyl)benzoyl]-1-piperazinyl]carbonyl]-5-[[4-(aminoiminomethyl)-1-piperazinyl]methyl]-, methyl ester;CBB-1007,CBB1007
CAS:1379573-92-8
MF:C27H34N8O4
MW:534.61
EINECS:
Product Categories:
Mol File:1379573-92-8.mol
CBB 1007 Structure
CBB 1007 Chemical Properties
storage temp. Store at -20°C
solubility Soluble in DMSO
form Powder
Safety Information
MSDS Information
CBB 1007 Usage And Synthesis
Biological Activitycbb1007 is an inhibitor of histone demethylase lsd1with ic50 values of 5.27μm [1].lsd1 is a member of the fad-dependent amine oxidase family. it converts di-methylated h3k4 to mono- and un-methylated h3k4 and suppresses gene expression. as an inhibitor of lsd1, cbb1007 is developed to understand the function of the enzyme. in the in vitro assay, cbb1007 shows highly potent inhibitory activity with ic50 value of 5.27μm. it is specific against lsd1 and has no effect on other histone demethylases including lsd2 and jarid1a. in the mouse f9 embryonic teratocarcinoma cells, cbb1007 cause a reproducible increase of mono- and di-methylated h3k4 with ic50 value of 1μm-5μm. it also activates the expression of chrm4 and scn3a which are the target genes of lsd1. the inhibition of lsd1 results in the growth inhibition of these cells. furthermore, cbb1007 is found to inhibit the proliferation of other pluripotent cancer cells as well as the embryonic stem cells that express the stem cell markers oct4 and sox2 [1].
references[1] wang j, lu f, ren q, et al. novel histone demethylase lsd1 inhibitors selectively target cancer cells with pluripotent stem cell properties. cancer research, 2011, 71(23): 7238-7249.
CBB 1007 Preparation Products And Raw materials
Tag:CBB 1007(1379573-92-8) Related Product Information