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J & K SCIENTIFIC LTD.
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Product Name:3',4'-DiMethoxy-α-naphthoflavone
CAS:14756-24-2
Package:100Mg,10Mg
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| | 3',4'-DiMethoxy-α-naphthoflavone Basic information |
| Product Name: | 3',4'-DiMethoxy-α-naphthoflavone | | Synonyms: | 3',4'-DiMethoxy-α-naphthoflavone;2-(3,4-Dimethoxyphenyl)-benzo[h]chromen-4-one;DiMNF;NSC 123391;2-(3,4-Dimethoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one;4H-Naphtho[1,2-b]pyran-4-one, 2-(3,4-dimethoxyphenyl)-;3',4'-DiMethoxy-α-naphthoflavone | | CAS: | 14756-24-2 | | MF: | C21H16O4 | | MW: | 332.35 | | EINECS: | | | Product Categories: | Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals | | Mol File: | 14756-24-2.mol |  |
| | 3',4'-DiMethoxy-α-naphthoflavone Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: ≥13mg/mL | | form | powder | | color | white to tan | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 |
| | 3',4'-DiMethoxy-α-naphthoflavone Usage And Synthesis |
| Description | DiMNF (14756-24-2) is a selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). It exhibits antiinflammatory activity including suppression of cytokine-mediated acute phase genes through dissociation of non-dioxin-response element (DRE) AHR activity from DRE-dependent xenobiotic gene expression.1?DiMNF represses the cytokine-mediated induction of CD55 and therefore may have therapeutic potential in regulating the immune response to tumor formation.2?Represses estrogen-inducible transcription.3 | | Uses | 3'',4''-Dimethoxy-α-naphthoflavone (DiMNF) is a potent and selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). Studies show that DiMNF suppresseses cytokine-mediated complement factor gene expression through selective activation of the Ah receptor. DiMNF has therapeutic potential in regulating the immune response to tumor formation. | | Uses | 3',4'-Dimethoxy-α-naphthoflavone (DiMNF) is a potent and selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). Studies show that DiMNF suppresseses cytokine-mediated complement factor gene expression through selective activation of the Ah receptor. DiMNF has therapeutic potential in regulating the immune response to tumor formation. | | References | 1) Murray?et al. (2011),?Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3’,4’-dimethoxy-α-naphthoflavone;? Mol. Pharmacol.,?79?508
2) Narayanan?et al. (2012),?Selective aryl hydrocarbon receptor modulator-mediated repression of CD55 expression induced by cytokine exposure;? J. Pharmacol. Exp. Ther.,?342?345
3) Labrecque?et al. (2012),?Distinct roles for aryl hydrocarbon receptor nuclear translocator and ah receptor in estrogen-mediated signaling in human cancer cell lines;? PLoS One,?7(1)?e29545 |
| | 3',4'-DiMethoxy-α-naphthoflavone Preparation Products And Raw materials |
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