2,5-二(1-氮丙啶基)-3-(羟甲基)-6-甲基-2,5-环己二烯-1,4-二酮
| 中文名称 | 2,5-二(1-氮丙啶基)-3-(羟甲基)-6-甲基-2,5-环己二烯-1,4-二酮 |
|---|---|
| 中文同义词 | 2,5-二(1-氮丙啶基)-3-(羟甲基)-6-甲基-2,5-环己二烯-1,4-二酮;化合物 T16740;化合物 RH1 |
| 英文名称 | NSC 697726 |
| 英文同义词 | NSC 697726;RH1;2,5-Di(1-aziridinyl)-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone;2,5-Bis(1-aziridinyl)-3-(hydroxymethyl)-6-methyl-2,5-cyclohexadiene-1,4-dione;2,5-bis(aziridin-1-yl)-3-(hydroxymethyl)-6-methylcyclohexa-2,5-diene-1,4-dione;2,5-Cyclohexadiene-1,4-dione, 2,5-bis(1-aziridinyl)-3-(hydroxymethyl)-6-methyl- |
| CAS号 | 221635-42-3 |
| 分子式 | C12H14N2O3 |
| 分子量 | 234.25 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 221635-42-3.mol |
| 结构式 |  |
2,5-二(1-氮丙啶基)-3-(羟甲基)-6-甲基-2,5-环己二烯-1,4-二酮 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 颜色 | 棕至红 |
RH1 (NSC 697726) 是一种有效的生物还原剂，在体外和体内具有显着的抗癌活性。
Treatment of NQ16 cells with RH1 (50 and 100 nM) for 60 and 120 min results in a significant increase (p< 0.05) in cross-linked DNA. RH1 induces apoptosis in a time- and concentration-dependent manner in NQ16 cells .
RH1 exhibits antitumor activity in a dose-dependent manner against NQ16 tumors growing in athymic mice. RH1 treatment (0.4 mg/kg and 0.2 mg/kg) of mice bearing NQ16 tumors results in a significant reduction in tumor volume between treated groups and controls as early as 5 days after the treatment period ended. Low-dose RH1 (0.1 mg/kg) also results in a significant reduction in tumor volume between treated mice and controls.