- Leukadherin 1
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- $1.00 / 1g
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2019-12-24
- CAS:344897-95-6
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 20kg
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| | Leukadherin 1 Basic information |
| Product Name: | Leukadherin 1 | | Synonyms: | Leukadherin 1;Leukadherin-1;4-[5-[[4-Oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-benzoic acid;Leukadhedrin 1;LA1(Leukadherin-1);CS-2237;LEUKADHERIN 1;LEUKADHERIN1;eukadherin-1 | | CAS: | 344897-95-6 | | MF: | C22H15NO4S2 | | MW: | 421.49 | | EINECS: | | | Product Categories: | API | | Mol File: | 344897-95-6.mol |  |
| | Leukadherin 1 Chemical Properties |
| Boiling point | 634.7±65.0 °C(Predicted) | | density | 1.50±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,2-8°C | | solubility | DMSO: soluble3mg/mL, clear (warmed) | | pka | 4.11±0.10(Predicted) | | form | powder | | color | , yellow to orange to brown |
| | Leukadherin 1 Usage And Synthesis |
| Uses | Leukadherin 1 is a small molecule agonist that enhances CD11b/CD18-dependent cell adhesion to its ligand ICAM-1 (1). Complement receptor 3 (CR3, CD11b/CD18) is a cell surface receptor expressed on myeloid and natural killer cells (2). | | Biological Activity | leukadherin 1 is an activator of cd11b/cd18 [1].cd11b/cd18 is a cell surface adhesion receptor that mediates immune functions and leukocyte migration and is expressed primarily in the cells of the innate immune system.leukadherin 1 is a cd11b/cd18 activator. leukadherin 1 increased cd11b/cd18-dependent cell adhesion to fibrinogen with ec50 value of 4 μm [1]. leukadherin 1 increased cd11b/cd18-dependent cell adhesion to its ligand icam-1. in k562 cells, leukadherin 1 increased the binding of cd11b/cd18 to icam-1 through the formation of long membrane tethers [2].in the acute peritonitis mice model, leukadherin 1 significantly reduced neutrophil accumulation by 40% [1]. in a mhc mismatched orthotopic kidney transplantation mouse model, leukadherin 1 reduced interstitial leukocyte infiltration, glomerular damage, neointimal hyperplasia and prolonged survival from 48.5% (csa only) to 100% (csa and la1) [3]. in newborn rats exposed to hyperoxia (85% o2), leukadherin 1 reduced both macrophage and neutrophil infiltration in the lungs [4]. | | references | [1]. maiguel d, faridi mh, wei c, et al. small molecule-mediated activation of the integrin cd11b/cd18 reduces inflammatory disease. sci signal, 2011, 4(189): ra57.
[2]. celik e1, faridi mh, kumar v, et al. agonist leukadherin-1 increases cd11b/cd18-dependent adhesion via membrane tethers. biophys j, 2013, 105(11): 2517-2527.
[3]. khan sq, guo l, cimbaluk dj, et al. a small molecule b2 integrin agonist improves chronic kidney allograft survival by reducing leukocyte recruitment and accompanying vasculopathy. front med (lausanne), 2014, 1: 45.
[4]. jagarapu j, kelchtermans j, rong m, et al. leukadherin-1 attenuates hyperoxia-induced lung injury in neonatal rats. am j respir cell mol biol, 2015. |
| | Leukadherin 1 Preparation Products And Raw materials |
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