|
|
| Product Name: | MF 438 | | Synonyms: | MF 438;2-methyl-5-[6-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]pyridazin-3-yl]-1,3,4-thiadiazole;3-(5-Methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]pyridazine;Pyridazine, 3-(5-methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]-;3-(5-Methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]pyridazine(MF-438);Stearoyl-CoA Desaturase (SCD),inhibit,MF438,MF 438,MF-438,Inhibitor | | CAS: | 921605-87-0 | | MF: | C19H18F3N5OS | | MW: | 421.44 | | EINECS: | | | Product Categories: | | | Mol File: | 921605-87-0.mol |  |
| | MF 438 Chemical Properties |
| Boiling point | 614.5±65.0 °C(Predicted) | | density | 1.365±0.06 g/cm3(Predicted) | | storage temp. | -20° | | solubility | Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 2 mg/ml with warming). | | form | solid | | pka | 2.29±0.10(Predicted) | | color | Off-white | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| | MF 438 Usage And Synthesis |
| Description | MF-438 (921605-87-0) is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) – IC50?= 2.3 nM.1?MF-438 was potent in an?in vivo?mouse liver PD assay (ED50?between 1 and 3 mg/kg).1?Cancer initiating cells (CSC-like) were shown to be much more sensitive to MF-438 inhibition of SCD1 than progenitor and terminally differentiated cancer cells in a lung cancer model.2?MF-438 showed good oral bioavailability and metabolic stability making it an excellent tool for studying the effects of SCD1 in various disease models. | | References | 1) Leger?et al. (2010),?Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438); Bioorg. Med. Chem. Lett.,?20?499
2) Noto?et al. (2013),?Stearoyl-CoA desaturase-1 is a key factor for lung cancer-initiating cells; Cell Death and Differ.,?4?e947
3) Rodriguez-Perez?et al.?(2017),?Altered fatty acid metabolism and reduced stearoyl-coenzyme A desaturase activity in asthma; Allergy,?72?1744 [Citation] |
| | MF 438 Preparation Products And Raw materials |
|