1449236-96-7
中文名称 | 1449236-96-7 |
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中文同义词 | 化合物 T12236;化合物NMS-859;2-氯-N-(3-((1,1-二氧代苯并[D]异噻唑-3-基)氨基)苯基)乙酰胺 |
英文名称 | 2-chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)phenyl)acetamide |
英文同义词 | 2-chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)phenyl)acetamide;2-Chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]phenyl}acetamide;Acetamide, 2-chloro-N-[3-[(1,1-dioxido-1,2-benzisothiazol-3-yl)amino]phenyl]- |
CAS号 | 1449236-96-7 |
分子式 | C15H12ClN3O3S |
分子量 | 349.79 |
EINECS号 | |
相关类别 | |
Mol文件 | 1449236-96-7.mol |
结构式 |
1449236-96-7 性质
密度 | 1.52±0.1 g/cm3(Predicted) |
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储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:≥ 42 mg/mL(120.07 mM) |
形态 | 固体 |
酸度系数(pKa) | 12.40±0.70(Predicted) |
颜色 | 白色至灰色 |
IC50: 360 nM (Cellular p97, 1 mM ATP), 370 nM (Cellular p97, 60 μM ATP)
NMS-859 is a potent VCP inhibitor, with IC 50 s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively. NMS-859 shows very weak inhibitory activity against VCP C522T . NMS-859 also suppresses the proliferation of cells, with IC 50 s of 3.5 μM and 3.0 μM in HCT116 and HeLa cell lines, respectively.