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| | T2-aminoalcohol hydrochloride Basic information |
| Product Name: | T2-aminoalcohol hydrochloride | | Synonyms: | (S)-4-(4-(2-amino-3-hydroxypropyl)-2,6-diiodophenoxy)phenol hydrochloride;T2AA hydrochloride;T2-aminoalcohol hydrochloride;(βS)-β-Amino-4-(4-hydroxyphenoxy)-3,5-diiodobenzenpropanol;Benzenepropanol, β-amino-4-(4-hydroxyphenoxy)-3,5-diiodo-, (βS)- | | CAS: | 1380782-27-3 | | MF: | C15H16ClI2NO3 | | MW: | 547.554 | | EINECS: | | | Product Categories: | | | Mol File: | 1380782-27-3.mol |  |
| | T2-aminoalcohol hydrochloride Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: soluble10mg/mL, clear | | form | powder | | color | white to beige |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26 | | WGK Germany | 3 |
| | T2-aminoalcohol hydrochloride Usage And Synthesis |
| Uses | T2AA is a small molecule inhibitor of PCNA/PIP-box interactions, which suppresses translesion DNA synthesis. | | Uses | T2AA hydrochloride has been used as a chemical inhibitor of proliferating cell nuclear antigen (PCNA) in vaccinia virus. | | Biochem/physiol Actions | T2AA is an inhibitor of PCNA/ PIP-Box interactions that binds to the PCNA cavity that interacts with PIP-Box sequences. Also T2AA inhibits PCNA Polδ3 interaction. T2AA inhibits de novo DNA synthesis, and in combination of cisplatin significantly increases growth inhibition in cancer cells. T2AA is a T3 analog that exhibits almost no thyroid hormone activity. | | storage | Store at -20°C |
| | T2-aminoalcohol hydrochloride Preparation Products And Raw materials |
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