(TYR5,D-TRP6·8·9,LYS-NH210)-NEUROKININ A (4-10)
中文名称 | (TYR5,D-TRP6·8·9,LYS-NH210)-NEUROKININ A (4-10) |
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中文同义词 | MEN 10376肽 |
英文名称 | H-ASP-TYR-D-TRP-VAL-D-TRP-D-TRP-LYS-NH2 |
英文同义词 | MEN 10376;H-ASP-TYR-D-TRP-VAL-D-TRP-D-TRP-LYS-NH2;ASP-TYR-D-TRP-VAL-D-TRP-D-TRP-LYS-NH2;[TYR5,D-TRP6,8 9,LYS10]-ALPHA-NEUROKININ A FRAGMENT 4-10;[TYR5, D-TRP6,8,9, LYS10]NEUROKININ A (4-10);(TYR5,D-TRP6,8,9,LYS-NH(2/10))-NEUROKININ A (4-10);tyr(5)-trp(6,8,9)-lys(10)-neurokinina(4-10;(tyr5,D-trp6,8,9,lys10)-A-neurokinin*fragment 4-1 |
CAS号 | 135306-85-3 |
分子式 | C57H68N12O10 |
分子量 | 1081.22 |
EINECS号 | |
相关类别 | 多肽;生化试剂;其他生化试剂;标准品;AntagonistPeptides for Cell Biology;Neuropeptides;Peptides for Cell Biology;Tachykinins;Tachykinin receptor;Peptide |
Mol文件 | 135306-85-3.mol |
结构式 |
(TYR5,D-TRP6·8·9,LYS-NH210)-NEUROKININ A (4-10) 性质
沸点 | 1555.4±65.0 °C(Predicted) |
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密度 | 1.361±0.06 g/cm3(Predicted) |
储存条件 | -20°C |
溶解度 | 溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。 |
形态 | 固体 |
酸度系数(pKa) | 3.71±0.10(Predicted) |
颜色 | 白色 |
Ki: 4.4 μM (NK-2 receptor, rat small intestine)
Men 10376 is a selective tachykinin NK-2 receptor, with a K i of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (K i , >10 μM). Men 10376 shows pA 2 s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (K i , >10 μM).
Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats.
安全信息
WGK Germany | 3 |
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提供商 | 语言 |
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英文
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