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| | Kobophenol A Basic information |
| Product Name: | Kobophenol A | | Synonyms: | Kobophenol A;(2S,2'R,3S,3'R)-3'-(3,5-Dihydroxyphenyl)-4-[(2S,3S,4R,5S)-4-(3,5-dihydroxyphenyl)tetrahydro-2,5-bis(4-hydroxyphenyl)-3-furanyl]-2,2',3,3'-tetrahydro-2,2'-bis(4-hydroxyphenyl)[3,4'-bibenzofuran]-6,6'-diol;[3,4'-Bibenzofuran]-6,6'-diol, 3'-(3,5-dihydroxyphenyl)-4-[(2S,3S,4R,5S)-4-(3,5-dihydroxyphenyl)tetrahydro-2,5-bis(4-hydroxyphenyl)-3-furanyl]-2,2',3,3'-tetrahydro-2,2'-bis(4-hydroxyphenyl)-, (2S,2'R,3S,3'R)-;Amobam Impurity 2 | | CAS: | 124027-58-3 | | MF: | C56H44O13 | | MW: | 924.94 | | EINECS: | | | Product Categories: | | | Mol File: | 124027-58-3.mol |  |
| | Kobophenol A Chemical Properties |
| Melting point | 233.5-235 °C (decomp) | | density | 1.497±0.06 g/cm3(Predicted) | | storage temp. | 4°C, away from moisture and light | | form | Solid | | pka | 9.25±0.10(Predicted) | | color | Off-white to light yellow |
| | Kobophenol A Usage And Synthesis |
| Biological Activity | Kobophenol A, an oligomeric stilbene, blocks the interaction between the ACE2 receptor and S1-RBD with an IC50 of 1.81 μM and inhibits SARS-CoV-2 viral infection in cells with an EC50 of 71.6 μM. Kobophenol A inhibits the activity of partially purified rat brain protein kinase C (PKC) with an IC50 of 52 μM[1][2]. | | References | [1]. Gangadevi S, et al. Kobophenol A Inhibits Binding of Host ACE2 Receptor with Spike RBD Domain of SARS-CoV-2, a Lead Compound for Blocking COVID-19. J Phys Chem Lett. 2021;12(7):1793-1802. [2]. Xu G, Zhang LP, Chen LF, Hu CQ. Yao Xue Xue Bao. 1994;29(11):818-822. |
| | Kobophenol A Preparation Products And Raw materials |
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