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| | E6446 (dihydrochloride) Basic information |
| Product Name: | E6446 (dihydrochloride) | | Synonyms: | E6446 (dihydrochloride);E6446 2HCl;E6446 HCl;E6446 hydrochloride;CS-2089;E6446;E 6446;E-6446;E-6446 DihydrochL;6-(3-(Pyrrolidin-1-yl)propoxy)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)benzo[d]oxazole dihydrochloride | | CAS: | 1345675-25-3 | | MF: | C27H36ClN3O3 | | MW: | 486.05 | | EINECS: | | | Product Categories: | API | | Mol File: | 1345675-25-3.mol |  |
| | E6446 (dihydrochloride) Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | DMSO:7.5(Max Conc. mg/mL);14.35(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);38.28(Max Conc. mM)
DMF:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.38(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);3.83(Max Conc. mM)
Water:100.0(Max Conc. mg/mL);191.38(Max Conc. mM) | | form | Solid | | color | White to off-white |
| | E6446 (dihydrochloride) Usage And Synthesis |
| Uses | E6446 is a synthetic antagonist of nucleic acid-sensing TLRs. , In vitro, low doses of E6446 specifically inhibited the activation of human and mouse TLR9. Tenfold higher concentrations of this compound also inhibited the human TLR8 response to single-stranded RNA. In vivo, therapy with E6446 diminished the activation of TLR9 and prevented the exacerbated cytokine response observed during acute Plasmodium infection. Furthermore, severe signs of ECM, such as limb paralysis, brain vascular leak, and death, were all prevented by oral treatment with E6446. |
| | E6446 (dihydrochloride) Preparation Products And Raw materials |
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