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| | PDE1-IN-1 (phosphate) Basic information |
| Product Name: | PDE1-IN-1 (phosphate) | | Synonyms: | PDE1-IN-1 (phosphate);ITI-214; ITI 214; ITI214; ITI-214 PHOSPHATE SALT.;ITI-214 phosphate;ITI-214 phosphate salt;ITI214;(6AR,9aS)-2-(4-(6-fluoropyridin-2-yl)benzyl)-5-methyl-3-(phenylamino)-5,6a,7,8,9,9a-hexahydrocyclopenta[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one phosphate;selective,oral,inhibit,motor,Phosphodiesterase (PDE),ITI 214,Inhibitor,ITI-214,cognitive,CNS-active;Lenrispodun phosphate | | CAS: | 1642303-38-5 | | MF: | C29H29FN7O5P | | MW: | 605.57 | | EINECS: | | | Product Categories: | | | Mol File: | 1642303-38-5.mol |  |
| | PDE1-IN-1 (phosphate) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO:30.0(Max Conc. mg/mL);49.54(Max Conc. mM) | | form | A solid | | color | White to off-white |
| | PDE1-IN-1 (phosphate) Usage And Synthesis |
| Description | ITI214 is an inhibitor of phosphodiesterase 1 (PDE1; Ki = 0.058 nM). It is selective for PDE1 over PDE2A, -3B, -4A, -5A, -6, -7B, -8A, -9A, -10A, and -11A (Kis = 0.16-18 μM). ITI214 (3 and 6 mg/kg) enhances novel object recognition in rats. It increases prefrontal cortex cAMP and cGMP levels in mice when administered at a dose of 50 mg/kg. ITI214 (0.1, 3, and 10 mg/kg) reverses MK-801-induced decreases in spontaneous alteration in the T-maze continuous alternation task in mice. |
| | PDE1-IN-1 (phosphate) Preparation Products And Raw materials |
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