- TM-38837
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- $8.00 / 1kg
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2024-04-24
- CAS:1253641-65-4
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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| | TM38837 Basic information |
| Product Name: | TM38837 | | Synonyms: | TM38837;peripheral,Cannabinoid Receptor,TM-38837,CB1,antiobesity,TM38837,inhibit,fat,TM 38837,Inhibitor,metabolic,fear;1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-4-ethyl-N-1-piperidinyl-5-[5-[2-[4-(trifluoromethyl)phenyl]ethynyl]-2-thienyl]- | | CAS: | 1253641-65-4 | | MF: | C30H25Cl2F3N4OS | | MW: | 617.51 | | EINECS: | | | Product Categories: | | | Mol File: | 1253641-65-4.mol |  |
| | TM38837 Chemical Properties |
| Melting point | 171-172 °C | | density | 1.38±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 41.67 mg/mL (67.48 mM) | | pka | 11.17±0.20(Predicted) |
| | TM38837 Usage And Synthesis |
| Biological Activity | TM38837 is a peripherally selective cannabinoid receptor type 1 (CB1) receptor antagonist. It has limited brain penetration to minimize or prevent CNS adverse effects and retain potential anti-obesity effects. Also it can reduces the propensity for psychotic side effects. | | in vivo | TM38837 (10-100 mg/kg; po) induces a significant increase in freezing behavior at 100 mg/kg. | Animal Model: | < td class="col2"> 7-8 weeks old male C57BL/6 N mice (B6N) | Dosage: | 10, 30, or 100 mg/kg | | Administration: | po < /td> | | Result: | High dose (100 mg/kg) induced a significant increase in freezing behavior. < /td> | | | target | | | storage | Store at -20°C |
| | TM38837 Preparation Products And Raw materials |
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