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| | Hydroxy-PEG3-PFP ester Basic information |
| Product Name: | Hydroxy-PEG3-PFP ester | | Synonyms: | Hydroxy-PEG3-PFP ester;Hydroxy-PEG3-C2-PFP ester;Propanoic acid, 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 2,3,4,5,6-pentafluorophenyl ester | | CAS: | 1807537-40-1 | | MF: | C15H17F5O6 | | MW: | 388.28 | | EINECS: | | | Product Categories: | | | Mol File: | 1807537-40-1.mol |  |
| | Hydroxy-PEG3-PFP ester Chemical Properties |
| Boiling point | 440.3±45.0 °C(Predicted) | | density | 1.385±0.06 g/cm3(Predicted) | | pka | 14.36±0.10(Predicted) |
| | Hydroxy-PEG3-PFP ester Usage And Synthesis |
| Biological Activity | Hydroxy-PEG3-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| | Hydroxy-PEG3-PFP ester Preparation Products And Raw materials |
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