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| | t-Boc-N-amido-PEG5-acid Basic information |
| Product Name: | t-Boc-N-amido-PEG5-acid | | Synonyms: | Boc-N-amido-PEG5-acid;t-boc-N-amido-PEG5-propionic acid;BOC-PEG5-CH2CH2COOH;T-BOC-NH-AMIDO-PEG5-COOH;5,8,11,14,17-Pentaoxa-2-azaeicosanedioic acid, 1-(1,1-dimethylethyl) ester;2,2-Dimethyl-4-oxo-3,8,11,14,17,20-hexaoxa-5-azatricosan-23-oic acid;BocNH-P5-COOH;BocNH-PEG5-CH2CH2COOH/5,8,11,14,17-Pentaoxa-2-azaeicosanedioic acid, 1-(1,1-dimethylethyl) ester | | CAS: | 1347750-78-0 | | MF: | C18H35NO9 | | MW: | 409.47 | | EINECS: | | | Product Categories: | peg | | Mol File: | 1347750-78-0.mol |  |
| | t-Boc-N-amido-PEG5-acid Chemical Properties |
| Boiling point | 536.9±50.0 °C(Predicted) | | density | 1.123±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 4.28±0.10(Predicted) | | form | Viscous Liquid | | color | Colorless to light yellow |
| | t-Boc-N-amido-PEG5-acid Usage And Synthesis |
| Description | t-Boc-N-amido-PEG5-acid is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine. | | Uses | Boc-NH-PEG5-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] Nathanael Gray, et al. Bifunctional compounds for her3 degradation and methods of use. WO2017117474A1. |
| | t-Boc-N-amido-PEG5-acid Preparation Products And Raw materials |
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