| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
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| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
Product Name:3-benzo[1,3]dioxol-5-ylmethylene-pyrrolidin-2-one
CAS:1859-42-3
Package:1g 5g 10g 100g
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| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:Heat Shock Protein Inhibitor II
CAS:1859-42-3
Purity:>98% Package:1mg;10mg;50mg;100mg;
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Heat Shock Protein Inhibitor II manufacturers
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| | Heat Shock Protein Inhibitor II Basic information |
| Product Name: | Heat Shock Protein Inhibitor II | | Synonyms: | 3-benzo[1,3]dioxol-5-ylmethylene-pyrrolidin-2-one;3-(Benzo[d][1,3]dioxol-5-ylmethylene)pyrrolidin-2-one;2-Pyrrolidinone, 3-(1,3-benzodioxol-5-ylmethylene)- | | CAS: | 1859-42-3 | | MF: | C12H11NO3 | | MW: | 217.22 | | EINECS: | | | Product Categories: | | | Mol File: | 1859-42-3.mol |  |
| | Heat Shock Protein Inhibitor II Chemical Properties |
| Melting point | 249-250 °C | | Boiling point | 466.9±45.0 °C(Predicted) | | density | 1.355±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.1 mg/ml | | form | A crystalline solid | | pka | 14.65±0.20(Predicted) |
| | Heat Shock Protein Inhibitor II Usage And Synthesis |
| Description | Heat shock protein (Hsp) inhibitor II is the active form of Hsp inhibitor I and a benzylidene lactam compound that prevents the synthesis of inducible Hsps, such as Hsp105, Hsp72, and Hsp40. Hsp inhibitor II decreases Hsp72 synthesis in vivo and reduces thermotolerance of tumors in SCC VII tumor-containing mice. At 100 μM, it inhibits the development of thermotolerance in COLO 320 DM cells. Inhibition of Hsp70 with Hsp inhibitor II in combination with amphotericin B (AmB; ) increases susceptibility of AmB-susceptible (MICs = 0.058 versus 0.27 μg/ml for combined and AmB alone, respectively) and AmB-resistant (MICs = 21.33 versus >32 μg/ml for combined and AmB alone, respectively) strains of A. fumigatus. |
| | Heat Shock Protein Inhibitor II Preparation Products And Raw materials |
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