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| | ONO 5334 Basic information |
| Product Name: | ONO 5334 | | Synonyms: | ONO 5334;ONO5334,ONO 5334;2H-Pyran-4-propanoic acid, β-[(cycloheptylcarbonyl)amino]tetrahydro-α-oxo-, (2Z)-2-[(4R)-3,4-dimethyl-2-thiazolidinylidene]hydrazide, (βS)- | | CAS: | 868273-90-9 | | MF: | C21H34N4O4S | | MW: | 438.59 | | EINECS: | | | Product Categories: | | | Mol File: | 868273-90-9.mol |  |
| | ONO 5334 Chemical Properties |
| density | 1.36±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | form | Solid | | pka | 7.06±0.40(Predicted) | | color | Off-white to light yellow |
| | ONO 5334 Usage And Synthesis |
| Uses | ONO 5334 is a novel cathepsin K inhibitor. Inhibited bone resorption in human osteoclast and reduced calcium level increased by PTHrP in thyroparathyroidectomized rat and decreased serum and urine C-telopeptide of type I collagen level in monkey. Values in postmenopausal patient with osteoporosis, increases lumbar spine, total hip and femoral neck bone minerals. |
| | ONO 5334 Preparation Products And Raw materials |
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