| Company Name: |
ChemShuttle, Inc.
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0510-83588313-802 18800520310; |
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sales@chemshuttle.com |
| Products Intro: |
Product Name:6-methyl-3-(2-nitro-1-(thiophen-2-yl)ethyl)-2-phenyl-1H-indole
CAS:1998197-39-9
Purity:95% Package:5mg;25mg;100mg;500mg;1g;5g;10g;25g;50g;100g;250g;500g;kg…
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| Company Name: |
BOC Sciences
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| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:ZCZ 011
CAS:1998197-39-9
Purity:99% Remarks:ZCZ 011 is a cannabinoid CB1 receptor positive allosteric modulator (PAM) which augments the binding of the CB1 orthosteric agonists CP55940 (pEC50 value 6.90) to CB1 and reduces neuropathic pain in t
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| | ZCZ 011 Basic information |
| Product Name: | ZCZ 011 | | Synonyms: | ZCZ 011;6-methyl-3-(2-nitro-1-(thiophen-2-yl)ethyl)-2-phenyl-1H-indole;184590;1H-Indole, 6-methyl-3-[2-nitro-1-(2-thienyl)ethyl]-2-phenyl- | | CAS: | 1998197-39-9 | | MF: | C21H18N2O2S | | MW: | 362.44 | | EINECS: | | | Product Categories: | | | Mol File: | 1998197-39-9.mol |  |
| | ZCZ 011 Chemical Properties |
| Boiling point | 602.8±55.0 °C(Predicted) | | density | 1.283±0.06 g/cm3(Predicted) | | pka | 7.52±0.18(Predicted) |
| | ZCZ 011 Usage And Synthesis |
| Description | ZCZ011 is a positive allosteric modulator of the cannabinoid CB1 receptor. ZCZ011 potentiated binding of [(3)H]CP55,940 to the CB1 receptor as well as enhancing AEA-stimulated [(35)S]GTPγS binding in mouse brain membranes and β-arrestin recruitment and ERK phosphorylation in hCB1 cells. In the whole animal, ZCZ011 is brain penetrant, increased the potency of these orthosteric agonists in mouse behavioral assays indicative of cannabimimetic activity, including antinociception, hypothermia, catalepsy, locomotor activity, and in the drug discrimination paradigm. ZCZ011 acts as a CB1 PAM and provide the first proof of principle that CB1 PAMs offer a promising strategy to treat neuropathic and inflammatory pain with minimal or no cannabimimetic side effects. |
| | ZCZ 011 Preparation Products And Raw materials |
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