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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627 |
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info@efebio.com |
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Product Name:(25S)-Δ7-Dafachronic Acid
CAS:949004-12-0
Purity:95% (HPLC) Package:100ug;500μg;1mg
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| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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400-9205774 |
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sales@glpbio.cn |
| Products Intro: |
Product Name:(25S)-δ7-Dafachronic Acid
CAS:949004-12-0
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
| Products Intro: |
Product Name:(25S)-Δ7-Dafachronic Acid
CAS:949004-12-0
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| | (25S)-Δ7-Dafachronic Acid Basic information |
| Product Name: | (25S)-Δ7-Dafachronic Acid | | Synonyms: | (25S)-Δ7-Dafachronic Acid;(25S)-Delta(7)-dafachronic acid;(2S,6R)-6-[(5S,9R,10S,13R,14R,17R)-10,13-dimethyl-3-oxo-1,2,4,5,6,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-methylheptanoic acid;Cholest-7-en-26-oic acid, 3-oxo-, (5α,25S)-;(25S)-delta-7-Dafachronic acid,(25S) delta7 Dafachronic acid,(25S)delta7Dafachronic acid;(5α,25S)-3-oxo-cholest-7-en-26-oicacid | | CAS: | 949004-12-0 | | MF: | C27H42O3 | | MW: | 414.62 | | EINECS: | | | Product Categories: | | | Mol File: | 949004-12-0.mol |  |
| | (25S)-Δ7-Dafachronic Acid Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 5 mg/ml; DMSO: 2.5 mg/ml; Ethanol: 12.5 mg/ml; Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml | | form | A crystalline solid | | color | White to off-white |
| | (25S)-Δ7-Dafachronic Acid Usage And Synthesis |
| Description | During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival. DAF-12 is an orphan nuclear hormone receptor that regulates dauer larva diapause, reproductive development, fat metabolism, and life cycle/longevity in C. elegans. DAF-12 is required for entry into dauer when it is not bound to ligand by acting as a transcriptional repressor of target genes that favor reproductive development. (25S)-Δ7-Dafachronic acid is a sterol-derived hormone that acts as a ligand of DAF-12 with an EC50 value of 23 nM. At 50 nM, (25S)-Δ7-Dafachronic acid inhibits the dauer-promoting activity of DAF-12, blocking the formation of infective larvae in several parasitic nematodes in favor of reproductive maturation to adults. Thus, selective ligand modulators of DAF-12 are a potential therapeutic approach to stop larvae progression during parasitic infection. | | Definition | ChEBI: A Delta7-dafachronic acid that has S configuration at position 25 (the carbon attached to the carboxy group). | | storage | +4°C |
| | (25S)-Δ7-Dafachronic Acid Preparation Products And Raw materials |
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