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BOC Sciences
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Product Name:17β-Hydroxy wortmannin
CAS:58053-83-1
Purity:98% Package:1G;10G;100G Remarks:17β-Hydroxy wortmannin is an analog of wortmannin. It irreversibly binds phosphoinositide 3-kinase (PI3K) and potently blocks fMLP-stimulated respiratory burst in neutrophils (IC50 = 5 nM).
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Shanghai Hongye Biotechnology Co. Ltd
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Product Name:17β-hydroxy Wortmannin
CAS:58053-83-1
Purity:>98% Package:1mg;10mg;50mg;100mg;
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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Product Name:17β-hydroxy Wortmannin
CAS:58053-83-1
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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MedBioPharmaceutical Technology Inc
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Product Name:17β-hydroxy Wortmannin
CAS:58053-83-1
Purity:98% Package:1mg; 5mg; 10mg; 500ug Remarks:Medbio
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Shanghai Yifei Biotechnology Co. , Ltd.
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Product Name:17β-hydroxy Wortmannin Exclusive
CAS:58053-83-1
Purity:98% Package:500μg;1mg;5mg
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| | 17β-hydroxy Wortmannin Basic information |
| Product Name: | 17β-hydroxy Wortmannin | | Synonyms: | 17β-hydroxy Wortmannin Exclusive;XLJORQYAOTYVQS-OGCOKEDGSA-N;17.beta.-hydroxy Wortmannin;PI 3-K Inhibitor XI, HWT - CAS 58053-83-1 - Calbiochem;3H-Furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6(1H)-dione, 11-(acetyloxy)-6b,7,8,9,9a,10,11,11b-octahydro-9-hydroxy-1-(methoxymethyl)-9a,11b-dimethyl-, (1S,6bR,9S,9aS,11R,11bR)-;17β-hydroxy Wortmannin;17β-hydroxy Wortmannin Exclusive | | CAS: | 58053-83-1 | | MF: | C23H26O8 | | MW: | 430.45 | | EINECS: | | | Product Categories: | | | Mol File: | 58053-83-1.mol |  |
| | 17β-hydroxy Wortmannin Chemical Properties |
| Boiling point | 615.4±55.0 °C(Predicted) | | density | 1.39±0.1 g/cm3(Predicted) | | storage temp. | +2C to +8C | | solubility | DMF: 3 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 2.5 mg/ml; Ethanol: 0.15 mg/ml | | form | Off-white solid | | pka | 14.49±0.70(Predicted) |
| | 17β-hydroxy Wortmannin Usage And Synthesis |
| Description | 17β-hydroxy Wortmannin is an analog of wortmannin. It irreversibly binds phosphoinositide 3-kinase (PI3K) and potently blocks fMLP-stimulated respiratory burst in neutrophils (IC50 = 5 nM). 17β-hydroxy Wortmannin inhibits recombinant PI3K and mTOR (IC50 = 2.7 and 193 nM, respectively) and prevents the growth of LNCap prostate cancer cells (IC50 = 1.46 μM). The 17-hydroxyl group has been used to further modify this compound, e.g., by pegylation and conjugation with rapamycin. |
| | 17β-hydroxy Wortmannin Preparation Products And Raw materials |
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