| Company Name: |
MQ (shanghai) Pharmaceuticals Co., Ltd.
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| Tel: |
13761635123 |
| Email: |
1014988033@qq.com |
| Products Intro: |
Product Name:Neutrophil Elastase Inhibitor
CAS:1448314-31-5
Purity:98%+ Package:10g,25g,100g,1kg
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Neutrophil Elastase Inhibitor
CAS:1448314-31-5
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
MedBioPharmaceutical Technology Inc
|
| Tel: |
021-69568360 18916172912 |
| Email: |
order@med-bio.cn |
| Products Intro: |
Product Name:Neutrophil Elastase Inhibitor
CAS:1448314-31-5
Purity:98% Package:50mg; 10mg; 25mg; 5mg Remarks:Medbio
|
| Company Name: |
Aikon International Limited
|
| Tel: |
18626450290 |
| Email: |
yftan@aikonchem.com |
| Products Intro: |
CAS:1448314-31-5
Purity:95% Package:5KG;1KG;10KG
|
|
| | Neutrophil Elastase Inhibitor Basic information |
| Product Name: | Neutrophil Elastase Inhibitor | | Synonyms: | Neutrophil Elastase Inhibitor;Neutrophil Elastase Inhibitor Exclusive;1-(3-methylbenzoyl)indazole-3-carbonitrile;1H-Indazole-3-carbonitrile, 1-(3-methylbenzoyl)-;Neutrophil elastase inhibitor 1 | | CAS: | 1448314-31-5 | | MF: | C16H11N3O | | MW: | 261.28 | | EINECS: | | | Product Categories: | | | Mol File: | 1448314-31-5.mol |  |
| | Neutrophil Elastase Inhibitor Chemical Properties |
| storage temp. | Store at -20°C | | solubility | ≤0.5mg/ml in ethanol;10mg/ml in DMSO;30mg/ml in dimethyl formamide | | form | crystalline solid |
| | Neutrophil Elastase Inhibitor Usage And Synthesis |
| Biological Activity | neutrophil elastase inhibitor is a neutrophil elastase inhibitor.human neutrophil elastase (hne) is a member of the chymotrypsin superfamily of serine proteases that is involved in the response to inflammatory stimuli. hne is reported to be stored in azurophilic granules of neutrophils and is greatly aggressive and cytotoxic, as its substrates include various components of the extracellular matrix. | | in vitro | previous study found that neutrophil elastase inhibitor was able to inhibit thrombin and urokinase at micromolar concentrations. in addition, neutrophil elastase inhibitor appeared to be a specific hne inhibitors in a competitive manner. moreoer, the hydrolysis of the acyl-enzyme complex for neutrophil elastase inhibitor was found to be much slower than spontaneous hydrolysis of neutrophil elastase inhibitor, and hne was observed to be still inhibited to 80% of control level at 7 h after treatment [1]. | | IC 50 | 7 nm | | references | [1] l. crocetti, i. a. schepetkin, a. cilibrizzi, et al. optimization of n-benzoylindazole derivatives as inhibitors of human neutrophil elastase. journal of medicinal chemistry 56(15), 6259-6272 (2013). |
| | Neutrophil Elastase Inhibitor Preparation Products And Raw materials |
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