- NH-bis(PEG1-OH)
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- $0.00 / 10g
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2024-03-29
- CAS:54384-47-3
- Min. Order: 10g
- Purity: >95.00%
- Supply Ability: 10g
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| | NH-(PEG1-OH)2 Basic information |
| Product Name: | NH-(PEG1-OH)2 | | Synonyms: | NH-(PEG1-OH)2;NH-bis(PEG1-OH);2-(2-{[2-(2-hydroxyethoxy)ethyl]amino}ethoxy)ethan-1-ol;NH-bis-PEG2;Ethanol, 2,2'-[iminobis(2,1-ethanediyloxy)]bis-;2,2’-[[Azanediylbis(ethane-2,1-diyl)]bis(oxy)]diethanol;2-[2-[2-(2-hydroxyethoxy)ethylamino]ethoxy]ethanol | | CAS: | 54384-47-3 | | MF: | C8H19NO4 | | MW: | 193.24 | | EINECS: | | | Product Categories: | | | Mol File: | 54384-47-3.mol |  |
| | NH-(PEG1-OH)2 Chemical Properties |
| Boiling point | 128 °C(Press: 0.02 Torr) | | density | 1.090±0.06 g/cm3(Predicted) | | solubility | Soluble in Water, DMSO, DCM, DMF | | pka | 14.09±0.10(Predicted) | | form | Liquid | | color | Colorless to light yellow |
| | NH-(PEG1-OH)2 Usage And Synthesis |
| Description | NH-bis(PEG1-OH) can be used to conjugate with carboxylic acid in the presence of HATU or EDC | | Biological Activity | NH-bis(PEG1-OH) is a non-cleavable 2-unit PEG ADC linker for the synthesis of antibody drug conjugates (ADCs). It is also a PEG-based PROTAC linker that can be used for PROTAC synthesis. | | in vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. | | target | | Non-cleavable < span> | PEGs | |
| | NH-(PEG1-OH)2 Preparation Products And Raw materials |
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