867164-40-7
中文名称 | 867164-40-7 |
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中文同义词 | TRC051384游离态;化合物TRC 051384;1-(2-吗啉乙基)-3-(4-(3-(6-吗啉吡啶-2-基)丙烯酰基)苯基)脲;TRC 051384,热休克蛋白HSP70的诱导物 |
英文名称 | TRC051384 |
英文同义词 | TRC051384;TRC 051384; TRC-051384;N-[2-(4-Morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]urea;Urea, N-[2-(4-morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]-;1-(2-Morpholinoethyl)-3-(4-(3-(6-morpholinopyridin-2-yl)acryloyl)phenyl)urea;HSP,TRC-051384,TRC051384,Heat shock proteins,Inhibitor,inhibit |
CAS号 | 867164-40-7 |
分子式 | C25H31N5O4 |
分子量 | 465.54 |
EINECS号 | |
相关类别 | API |
Mol文件 | 867164-40-7.mol |
结构式 | ![]() |
867164-40-7 性质
沸点 | 685.7±55.0 °C(Predicted) |
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密度 | 1.260±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 不溶于乙醇;不溶于水; DMSO 中≥109 mg/mL |
形态 | 固体 |
酸度系数(pKa) | 13.47±0.46(Predicted) |
颜色 | 粘黄色 |
HSP70
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TRC051384, dose dependently induces HSP70B mRNA by several hundred folds in both HeLa and rat primary mixed neurons. Treatment with TRC051384 results in significant dose-dependent increase in HSF1 transcriptional activity and recovery of luciferase activity. TRC051384 results in 60% inhibition at 6.25 μM and 90% inhibition at 12.5 μM of LPS-induced TNF-α expression in differentiated THP-1 cell line.
Treatment with TRC051384 significantly reduces stroke associated neuronal injury (87% reduction in area of penumbra recruited to infarct, and 25% reduction in brain edema) and disability in a rat model of transient ischemic stroke even when administered 8 hours post onset of ischemia. Significant improvement in survival (50% by day2 and 67.3% by day 7) is observed with TRC051384 treatment initiated at 4 hours after ischemia onset. Induction of HSP70 by TRC051384 involves HSF1 activation and results in elevated chaperone and anti-inflammatory activity.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-101712 | TRC051384 | 1 mg | 400元 | |
2024/08/19 | HY-101712 | 867164-40-7 TRC051384 | 867164-40-7 | 5mg | 900元 |