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| | AM-2099 Basic information |
| Product Name: | AM-2099 | | Synonyms: | AM-2099;AM 2099;AM-2099;7-Quinazolinesulfonamide, 4-[2-methoxy-4-(trifluoromethyl)phenyl]-N-2-thiazolyl-;4-[2-Methoxy-4-(trifluoromethyl)phenyl]-N-2-thiazolyl-7-quinazolinesulfonamide | | CAS: | 1443373-17-8 | | MF: | C19H13F3N4O3S2 | | MW: | 466.46 | | EINECS: | | | Product Categories: | | | Mol File: | 1443373-17-8.mol |  |
| | AM-2099 Chemical Properties |
| Boiling point | 572.1±60.0 °C(Predicted) | | density | 1.531±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : ≥ 150 mg/mL (321.57 mM) | | form | Solid | | pka | 6.11±0.50(Predicted) | | color | White to off-white |
| | AM-2099 Usage And Synthesis |
| Description | AM-2099 is a potent and selective NaV1.7 Inhibitor (hNav1.7 IC50 = 0.16 uM; hNav1.5 IC50 > 30 uM; Papp = 31 x 10 (-6)cm/s; Rat IV CL (b/h/kg) \= 0.54; cLogD = 2.1). AM-2099 demonstrated a favorable pharmacokinetic profile in rat and dog and demonstrated dose-dependent reduction of histamine-induced scratching bouts in a mouse behavioral model following oral dosing. |
| | AM-2099 Preparation Products And Raw materials |
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