| Company Name: |
MedChemexpress LLC
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| Tel: |
021-58955995 |
| Email: |
sales@medchemexpress.cn |
| Products Intro: |
Product Name:Ac-Gly-BoroPro
CAS:886992-99-0
Purity:110RMB/1mg Package:>98%
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| Company Name: |
BOC Sciences
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| Tel: |
|
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:Ac-Gly-BoroPro
CAS:886992-99-0
Remarks:A selective FAP inhibitor (Ki= 23 nM)
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| | Ac-Gly-BoroPro Basic information |
| Product Name: | Ac-Gly-BoroPro | | Synonyms: | Ac-Gly-BoroPro;Ac-Gly-BoroPro?, >98%;Boronic acid, B-[(2S)-1-[2-(acetylamino)acetyl]-2-pyrrolidinyl]-;AcGlyBoroPro,Ac Gly BoroPro | | CAS: | 886992-99-0 | | MF: | C8H15BN2O4 | | MW: | 214.03 | | EINECS: | | | Product Categories: | | | Mol File: | 886992-99-0.mol |  |
| | Ac-Gly-BoroPro Chemical Properties |
| density | 1.26±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C,unstable in solution, ready to use. | | solubility | DMSO : ≥ 50 mg/mL (233.61 mM) | | form | Solid | | pka | 9.72±0.20(Predicted) | | color | White to off-white |
| | Ac-Gly-BoroPro Usage And Synthesis |
| Biological Activity | Ac-Gly-BoroPro is a selective FAP inhibitor with a Ki value of 23 nM. | | in vitro | FAP has been implicated in cancer; however, its specific role remains elusive because inhibitors that distinguish FAP from other prolyl peptidases like dipeptidyl peptidase-4 (DPP-4) have not been developed. Ac-Gly-BoroPro selectively inhibits FAP relative to other prolyl peptidases. FAP reacts readily with submicromolar concentrations of Ac-Gly-BoroPro, reaching steady state inhibition levels rapidly (K i =23±3 nM). | | target | |
| | Ac-Gly-BoroPro Preparation Products And Raw materials |
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