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MZ 1

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Company Name: Shanghai finete Pharmaceutical Co., Ltd.
Tel: +86-18221039705
Email:
Products Intro: Product Name:MZ1
CAS:1797406-69-9
Purity:98% Package:1mg;5mg; 10mg;50mg;
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:MZ 1( MZ-1)
CAS:1797406-69-9
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:MZ 1
CAS:1797406-69-9
Purity:>=98% Package:10 mg Remarks:BOC Sciences also provides custom synthesis services for MZ 1.
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 +8613203830695
Email: laboratory@coreychem.com
Products Intro: Product Name: MZ 1
CAS:1797406-69-9
Purity:above 99% Package:1g;2USD
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
Email: sales@hzclap.com
Products Intro: Product Name:MZ1
CAS:1797406-69-9
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good

MZ 1 manufacturers

  • MZ 1
  • MZ 1 pictures
  • $0.00 / 1mg
  • 2024-08-30
  • CAS:1797406-69-9
  • Min. Order: 1mg
  • Purity: 98%min
  • Supply Ability: 500mg
MZ 1 Basic information
Product Name:MZ 1
Synonyms:MZ 1;(2S,4R)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;MZ-1;MZ 1;L-Prolinamide, N-[14-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1,13-dioxo-3,6,9-trioxa-12-azatetradec-1-yl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-N-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;cells,MZ-1,protein,Inhibitor,Degrader,PROTACs,Epigenetic Reader Domain,BRD4,selective,degradation,LS174t,MZ 1,MZ1,inhibit
CAS:1797406-69-9
MF:C49H60ClN9O8S2
MW:1002.64
EINECS:
Product Categories:
Mol File:1797406-69-9.mol
MZ 1 Structure
MZ 1 Chemical Properties
density 1.39±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO:30.0(Max Conc. mg/mL);29.9(Max Conc. mM)
form A crystalline solid
pka13.54±0.46(Predicted)
color White to light yellow
Safety Information
HS Code 2934100090
MSDS Information
MZ 1 Usage And Synthesis
DescriptionMZ1 is a hybrid compound that drives the selective proteasomal degradation of bromodomain-containing protein 4 (BRD4). It is characterized as a proteolysis-targeting chimera (PROTAC) and contains JQ-1, which binds bromo- and extra-terminal (BET) proteins, linked to a ligand for the E3 ubiquitin ligase VHL. MZ1 induces the selective degradation of BRD4 in HeLa cells when used at 0.1-0.5 μM. At concentrations of 2-10 μM, MZ1 causes the removal of BRD2, BRD3, and BRD4. BRD protein removal is evident within four hours of adding MZ1 and persists for at least 48 hours, unless MZ1 is removed.
UsesMZ 1, is a BRD4 protein degrader based on PROTAC technology. The Bromo- and Extra-Terminal (BET) proteins BRD2, BRD3, and BRD4 play important roles in transcriptional regulation, epigenetics, and cancer and are the targets of pan-BET selective bromodomain inhibitor JQ1.
DefinitionChEBI: MZ1 is an organic molecular entity.
storageStore at -20°C
MZ 1 Preparation Products And Raw materials
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