|
|
| | DBCO-PEG4-NHS ester Basic information |
| Product Name: | DBCO-PEG4-NHS ester | | Synonyms: | DBCO-NHCO-PEG4-NHS ester;4,7,10,13-Tetraoxa-17-azaeicosanoic acid, 20-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-16,20-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester | | CAS: | 2100306-58-7 | | MF: | C34H39N3O10 | | MW: | 649.69 | | EINECS: | | | Product Categories: | | | Mol File: | 2100306-58-7.mol |  |
| | DBCO-PEG4-NHS ester Chemical Properties |
| density | 1.33±0.1 g/cm3(Predicted) | | pka | 15.14±0.46(Predicted) |
| | DBCO-PEG4-NHS ester Usage And Synthesis |
| Description | DBCO-NHCO-PEG4-NHS ester is a PEG linker containing NHS ester that is able to react specifically and efficiently with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and can also provide a long and flexible connection that minimizes steric hindrance during ligation. DBCO is commonly used for copper-free Click Chemistry reactions. | | Biological Activity | DBCO-NHCO-PEG4-NHS ester is a PROTAC linker, belonging to the PEG class and the Alkyl/ether class. It can be used to synthesize a series of PROTAC molecules. Also it is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). | | in vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | | target | | Cleavable | PEGs | Alkyl/ether | |
| | DBCO-PEG4-NHS ester Preparation Products And Raw materials |
|