|
|
| | ABBV-744 Basic information |
| Product Name: | ABBV-744 | | Synonyms: | ABBV-744;CPD1639;CS-2875;ABBV-744; ABBV 744; ABBV744;2138861-99-9;N-Ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(1-hydroxy-1-methylethyl)phenyl]-6,7-dihydro-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide;1H-Pyrrolo[2,3-c]pyridine-2-carboxamide, N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(1-hydroxy-1-methylethyl)phenyl]-6,7-dihydro-6-methyl-7-oxo-;N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-h ydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-1H,6H, 7H-pyrrolo[2,3-c]pyridine-2-carboxamide;ABBV 744,Inhibitor,Antitumor,Selective,Oral,inhibit,Potent,Epigenetic Reader Domain,Drug-like,Human immunodeficiency virus,LNCaP,CYP3A4,ABBV-744,HIV | | CAS: | 2138861-99-9 | | MF: | C28H30FN3O4 | | MW: | 491.55 | | EINECS: | | | Product Categories: | | | Mol File: | 2138861-99-9.mol |  |
| | ABBV-744 Chemical Properties |
| Boiling point | 663.7±55.0 °C(Predicted) | | density | 1.262±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:33.57(Max Conc. mg/mL);68.29(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.51(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);61.03(Max Conc. mM) | | form | A crystalline solid | | pka | 13.77±0.40(Predicted) |
| | ABBV-744 Usage And Synthesis |
| Uses | ABBV 744 is a bromodomain and extra-??terminal (BET) inhibitor used as a combination therapy for cancer treatment. | | Biological Activity | ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2, BRD3 and BRD4. It can be further studied for the treatment of acute myeloid leukemia and cancer. | | in vitro | ABBV-744 is a potent BDII inhibitor that inhibits BRD2/3/4. The binding preference for BDII is more than 250 times that for BDI, with favorable drug-like properties. It is also an inhibitor of the androgen receptor transduction pathway. | | in vivo | The maximum tolerated dose of ABBV-744 induces tumor growth inhibition in AML and prostate cancer xenograft models. | | target |
| | ABBV-744 Preparation Products And Raw materials |
|
|
Tag:ABBV-744(2138861-99-9)
Related Product Information
|
|
BAY 299
T-26c
AZD-7594
4-[4-(1-methyl-1H-pyrazol-4-yl)-1-[2-(1-methyl-1H-pyrazol-4-yl)ethyl]-1H-imidazol-5-yl]-benzonitrile
Zofluza intermediate
RGX-104 HCl
Adavivint
|
According to the laws, regulations and policies related to "patent products", the sale of this product is prohibited!
ChemicalBook prompt
The patent owner or licensee of the product has not released any relevant information for the time being.
|