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| Product Name: | JT010 | | Synonyms: | JT010;2-Chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)acetamide;Acetamide, 2-chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)-;2-chloro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-methoxypropyl)acetamide;JT010,JT-010,TRP Channel,Transient receptor potential channels,inhibit,Inhibitor,JT 010 | | CAS: | 917562-33-5 | | MF: | C16H19ClN2O3S | | MW: | 354.85 | | EINECS: | | | Product Categories: | | | Mol File: | 917562-33-5.mol |  |
| | JT010 Chemical Properties |
| Boiling point | 487.4±55.0 °C(Predicted) | | density | 1.265±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | powder | | pka | 2.59±0.10(Predicted) | | color | white to beige |
| | JT010 Usage And Synthesis |
| Description | JT010 is a transient receptor potential ankyrin 1 (TRPA1) agonist (EC50 = 0.65 nM in a calcium influx assay). It is selective for TRPA1 over TRP vanilloid 1 (TRPV1), TRPV3, TRPV4, TRP canonical channel 5 (TRPC5), TRP melastatin 2 (TRPM2), and TRPM8 channels at 1 μM. | | Uses | JT010 is a potent and selective TRPA1 channel activator (EC50 = 65 nM); activates the TRPA1 channel by covalently and site-selectively binding to Cys621. Exhibits selectivity for TRPA1 over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC50 values are >1 μM). | | Biochem/physiol Actions | JT010 is a non-cytotoxic and highly stable (>90% remains after 2 h in 1 mM DTT or 2-mercaptoethanol) chloroacetamido warhead-carrying thiazole derivative that acts as a potent and TRPA1-selective channel activator via covalent modification of TRPA1 active site Cys621. JT0101 stimulates calcium influx in TRPA1-transfected HEK293 cells in a dose-dependent manner (EC50?= 650 pM) with excellent selectivity over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC50?>1 μM). | | storage | Store at +4°C |
| | JT010 Preparation Products And Raw materials |
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