| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing1@energy-chemical.com |
| Products Intro: |
Product Name:Etofenamate-d4
CAS:1329837-73-1
Purity:NULL Package:10mg;1mg Remarks:NULL
|
| Company Name: |
ChemeGen 中国
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Etofenamate-d4
CAS:1329837-73-1
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:Etofenamate-d4
CAS:1329837-73-1
Purity:>95% Package:5mg
|
|
| | XILVEPYQJIOVNB-ZEJCXXMWSA-N Basic information |
| | XILVEPYQJIOVNB-ZEJCXXMWSA-N Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Acetonitrile: soluble,Methanol: soluble | | form | An oil |
| | XILVEPYQJIOVNB-ZEJCXXMWSA-N Usage And Synthesis |
| Uses | Medication used to alleviate joint and muscle pain. | | Biological Activity | Etofenamate-d4 is intended for use as an internal standard for the quantification of etofenamate by GC- or LC-MS. Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) and diethylene glycol ester form of flufenamic acid that has anti-inflammatory and analgesic activities.1,2 It inhibits lipoxygenase isolated from guinea pig leukocytes (IC50 = 5.3 μM) and the production of prostaglandin E2 in stimulated rat peritoneal macrophages.2 In vivo, etofenamate reduces acetic acid-induced vascular permeability in mice and UV-induced erythema in guinea pigs in a dose-dependent manner at doses ranging from 40-320 and 5-20 mg/kg, respectively.1 Etofenamate (40 mg/kg per day for 21 days) inhibits inflammation in a rat model of adjuvant-induced arthritis. It also decreases the pain response in a silver nitrate-induced rat model of arthritis and the acetic acid-induced writhing test in mice, indicating analgesic activity. Formulations containing etofenamate have been used in the treatment of osteoarthritis. | | References | 1.Nakamura, H., Motoyoshi, S., Imazu, C., et al.Anti-inflammatory, analgesic and anti-pyretic activities of a non-steroidal anti-inflammatory drug, etofenamate, in experimental animalsNihon Yakurigaku Zasshi.80(2)125-135(1982)
2.Nakamura, H., Motoyoshi, S., Ishii, K., et al.The mode of anti-inflammatory action of a topical non-steroidal anti-inflammatory drug, etofenamateNihon Yakurigaku Zasshi.89(1)15-24(1987) |
| | XILVEPYQJIOVNB-ZEJCXXMWSA-N Preparation Products And Raw materials |
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