| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:11-deoxy-11-methylene-15-keto Prostaglandin D2
CAS:958759-75-6
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
Cayman Chemical Company
|
| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:11-deoxy-11-methylene-15-keto Prostaglandin D2
CAS:958759-75-6
Package:>98% Remarks:12415
|
| Company Name: |
Absin Bioscience Inc.
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| Tel: |
021-38015121 |
| Email: |
chenjw@absin.cn |
| Products Intro: |
Product Name:11-deoxy-11-methylene-15-keto Prostaglandin D2
CAS:958759-75-6
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| | 11-DEOXY-11-METHYLENE-15-KETO PROSTAGLANDIN D2 Basic information |
| Product Name: | 11-DEOXY-11-METHYLENE-15-KETO PROSTAGLANDIN D2 | | Synonyms: | 9ALPHA,HYDROXY-11-METHYLENE-15-OXO-PROSTA-5Z,13E-DIEN-1-OIC ACID;11-DEOXY-11-METHYLENE-15-KETO PROSTAGLANDIN D2;SAAKCJFTIGHOEX-WQXLGBCHSA-N;Prosta-5,13-dien-1-oic acid, 9-hydroxy-11-methylene-15-oxo-, (5Z,9α,13E)- | | CAS: | 958759-75-6 | | MF: | C21H32O4 | | MW: | 348.48 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | 11-DEOXY-11-METHYLENE-15-KETO PROSTAGLANDIN D2 Chemical Properties |
| solubility | DMF: 100 mg/ml; DMSO: 100 mg/ml; Ethanol: 100 mg/ml; PBS (pH 7.2): 2 mg/ml |
| | 11-DEOXY-11-METHYLENE-15-KETO PROSTAGLANDIN D2 Usage And Synthesis |
| Description | Prostaglandin D2 (PGD2) is one of the five primary enzymatic prostaglandins derived directly from PGH2. Many of the biological effects of PGD2 are transduced in vivo by a classical 7-transmembrane GPCR, the DP1 receptor.1 However, a second receptor, the chemokine-related CRTH2 receptor, also binds PGD2.2,3 This new receptor was recently identified on human eosinophils, where it binds selectively the PGD2 metabolite 13,14-dihydro-15-keto PGD2.4 11-deoxy-11-methylene-15-keto PGD2 was prepared as a more chemically stable ligand for this receptor. There are no published studies of the pharmacological properties of 11-deoxy-11-methylene-15-keto PGD2. | | Definition | ChEBI: 11-Deoxy-11-methylene-15-keto-PGD2 is a prostanoid. | | References | 1. Boie, Y., Sawyer, N., Slipetz, D.M., et al. Molecular cloning and characterization of the human prostanoid DP receptor J. Biol. Chem. 270(32),18910-18916(1995).
2. Gervais, F.G., Cruz, R., Chateauneuf, A., et al. Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP J. Allergy Clin. Immunol. 108(6),982-988(2002).
3. Monneret, G., Gravel, S., Diamond, M., et al. Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor Blood 98(6),1942-1948(2001).
4. Hirai, H., Tanaka, K., Yoshie, O., et al. Prostaglandin D2 selectivity induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2 J. Exp. Med. 193(2),255-261(2001). |
| | 11-DEOXY-11-METHYLENE-15-KETO PROSTAGLANDIN D2 Preparation Products And Raw materials |
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