| Company Name: |
Jinan blalong chemical co. LTD
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| Tel: |
2710913286@.com |
| Email: |
1513643261@qq.com |
| Products Intro: |
Product Name:MaytansinoidDM4Impurity1
CAS:796073-68-2
Purity:99% HPLC Package:50G;10G;1G;500MG;100MG
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| | DM4-Sme Basic information |
| Product Name: | DM4-Sme | | Synonyms: | DM4-Sme;Maytansine, N2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]-;Maytansinoid DM4 Impurity 1;Maytansinoid DM4 Impurity 1-d6 | | CAS: | 796073-68-2 | | MF: | C39H56ClN3O10S2 | | MW: | 826.46 | | EINECS: | | | Product Categories: | | | Mol File: | 796073-68-2.mol |  |
| | DM4-Sme Chemical Properties |
| Boiling point | 963.8±65.0 °C(Predicted) | | density | 1.30±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 9.82±0.70(Predicted) | | color | White to off-white | | InChIKey | LTLNAIFGVAUBEJ-GPEBISKRNA-N |
| | DM4-Sme Usage And Synthesis |
| Description | DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM[1][2]. | | References | [1]. Widdison W, et al. Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. Mol Pharm. 2015 Jun 1;12(6):1762-73.
[2]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8). |
| | DM4-Sme Preparation Products And Raw materials |
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