LU AE98134
| 中文名称 | LU AE98134 |
|---|---|
| 中文同义词 | |
| 英文名称 | N-butyl-4-methoxy-3-(6-methyl[1,2,4]triazolo[3,4-a]phthalazin-3-yl)benzenesulfonamide |
| 英文同义词 | N-butyl-4-methoxy-3-(6-methyl[1,2,4]triazolo[3,4-a]phthalazin-3-yl)benzenesulfonamide;Benzenesulfonamide, N-butyl-4-methoxy-3-(6-methyl-1,2,4-triazolo[3,4-a]phthalazin-3-yl)-;Lu AE98134;Lu AE98134,Lu AE-98134 |
| CAS号 | 849000-18-6 |
| 分子式 | C21H23N5O3S |
| 分子量 | 425.5 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 849000-18-6.mol |
| 结构式 |  |
LU AE98134 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 二甲基亚砜：250 mg/mL（587.54 mM） |
| 形态 | 固体 |
| 颜色 | 浅黄至黄色 |
Lu AE98134 (30 μM) promotes the current mediated by Nav v 1.1 channel, and it activates Na v 1.5 and to a lesser extent Na v 1.2 but has no effect on Na v 1.4, Na v 1.6 and Na v 1.7 currents in HEK cells expressing Na v 1.1, Na v 1.2, Na v 1.6, Na v 1.5, and Na v 1.7 by step-wise depolarizing voltages using the whole-cell patchclamp configuration. Lu AE98134 (30 μM) increases the excitability of FSINs by decreasing the threshold for action potentials.Intracellular depolarizing current pulses evokes repetitive firing of action potentials at frequencies, additionally, Lu AE98134 increases the excitability since each current pulse generated a higher number of spikes (163 spikes in control; and 230 spikes in Lu AE98134).
The fast spiking inhibitory interneurons (FSINs) from Dlx5/6 +/− animals exhibit abnormal excitability because of a more depolarized spike threshold and broader action potentials. Lu AE98134 (30 μM) increases the excitability of FSINs neurons from normal and Dlx5/6 +/− animals by modulating several parameters characteristic for NaV 1.1 channels. The selective activation of FSINs by Lu AE98134 restores cognitive flexibility in adult Dlx5/6 +/− mice.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-133910 | Lu AE98134 | 1 mg | 1590元 | |
| 2024/04/30 | HY-133910 | Lu AE98134 | 849000-18-6 | 5mg | 3500元 |