| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Anti-Perilipin A
Purity:affinity isolated antibody, buffered aqueous solution Package:200μL Remarks:P1998
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| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
Remarks:affinity isolated antibody, buffered aqueous solution
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| Company Name: |
SIGMA-RBI
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| Tel: |
800 736 3690 (Orders) |
| Email: |
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| Products Intro: |
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| Company Name: |
Fluorochem Ltd
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| Tel: |
(01457) 868921 (4 lines) |
| Email: |
vernam@fluorochem.co.uk |
| Products Intro: |
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| Company Name: |
Fluorochem Ltd.
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| Tel: |
+44 1457 868921 |
| Email: |
enquiries@fluorochem.co.uk |
| Products Intro: |
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| | ANTI-PERILIPIN A Basic information |
| | ANTI-PERILIPIN A Chemical Properties |
| storage temp. | −20°C | | form | buffered aqueous solution |
| | ANTI-PERILIPIN A Usage And Synthesis |
| Uses | Anti-Perilipin A antibody produced in rabbit has also been used in:
- indirect immunofluorescence
- immunoblotting
- immunohistochemistry
| | General Description | Perilipin is an intracellular neutral lipid storage droplet surface protein in white and brown fat adipocytes. It is also found in lower quantity coating droplets in steroidogenic-cells of the adrenal cortex, ovaries and testicular Leydig cells, on the surface of smaller droplets containing cholesteryl esters. Perilipin has multiple isoforms, resulting from differential splicing events. Perilipin A is most abundant in adipocytes and steroidogenic cells. Perilipin B is a minor form in adipocytes. Steroidogenic cells selectively express perilipins C and D. | | Biochem/physiol Actions | Perilipin is a gatekeeper protein that is involved in regulating triacylglycerol storage in adipocyte through the suppression of basal lipolysis apparently through protecting triacylglycerol against hydrolysis. Perilipin also enhances cyclic adenosine monophosphate (c-AMP)-dependent protein kinase (PKA)-stimulated lipolysis by hormone-sensitive lipase (HSL) and non-HSLs. Perilipin knockout mice exhibit reduced adipose tissue mass and resistance to diet induced obesity. Their lipid storage droplets are coated with adipose differentiation-related protein (ADRP, adipophilin), which is not phosphorylated by PKA. |
| | ANTI-PERILIPIN A Preparation Products And Raw materials |
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