ethyl 5-(2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl)furan-2-carboxylate manufacturers
- MMG-11
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- $58.00 / 2mg
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2024-10-24
- CAS:313254-94-3
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | ethyl 5-(2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl)furan-2-carboxylate Basic information |
| | ethyl 5-(2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl)furan-2-carboxylate Chemical Properties |
| Boiling point | 565.6±50.0 °C(Predicted) | | density | 1.430±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 100 mg/mL (326.51 mM; Need ultrasonic) | | form | Solid | | pka | 7.05±0.40(Predicted) | | color | Light yellow to brown |
| | ethyl 5-(2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl)furan-2-carboxylate Usage And Synthesis |
| Biological Activity | MMG-11 is a potent and selective human TLR2 antagonist with low cytotoxicity. MMG-11 inhibits both TLR2/1 and TLR2/6 signaling with IC50s of 1.7 μM for Pam3CSK4-induced hTLR2/1 and 5.7 μM for Pam2CSK4-induced hTLR2/6 responses[1].
MMG-11 neither shows cellular toxicity nor interference with signaling induced by other TLR agonists, IL-1β or TNF. MMG-11 (0.01-100 μM) shows no cytotoxic effects up to 100 μM in peripheral blood mononuclear cells (PBMCs)[1]. | | storage | Store at -20°C | | References | [1]. Grabowski M, et al. Identification of a pyrogallol derivative as a potent and selective human TLR2 antagonist by structure-based virtual screening. Biochem Pharmacol. 2018 Aug;154:148-160. |
| | ethyl 5-(2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl)furan-2-carboxylate Preparation Products And Raw materials |
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