中文名称 | AMPHOTERICIN B TRIHYDRATE |
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中文同义词 | |
英文名称 | AMPHOTERICIN B TRIHYDRATE |
英文同义词 | AMPHOTERICIN B TRIHYDRATE |
CAS号 | 1397-89-3 |
分子式 | C47H79NO20 |
分子量 | 978.12 |
EINECS号 | |
相关类别 | |
Mol文件 | Mol File |
结构式 |
AMPHOTERICIN B TRIHYDRATE 性质
储存条件 | 2-8°C |
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颜色 | 来自 DMF 的深黄色棱镜 |
Amphotericin B interacts with cholesterol, the major sterol of mammal membranes, thus limiting the usefulness of Amphotericin B due to its relatively high toxicity. Amphotericin B is dispersed as a pre-micellar or as a highly aggregated state in the subphase. Amphotericin B only kills unicellular Leishmania promastigotes (LPs) when aqueous pores permeable to small cations and anions are formed. Amphotericin B (0.1 mM) induces a polarization potential, indicating K + leakage in KCl-loaded liposomes suspended in an iso-osmotic sucrose solution. Amphotericin B (0.05 mM) exhibits a nearly total collapse of the negative membrane potential, indicating Na + entry into the cells.
Amphotericin B results in prolonging the incubation time and decreasing PrPSc accumulation in the hamster scrapie model. Amphotericin B markedly reduces PrPSc levels in mice with transmissible subacute spongiform encephalopathies (TSSE). Amphotericin B exerts a direct effect on Plasmodium falciparum and influences eryptosis of infected erythrocytes, parasitemia and hostsurvival in murine malaria. Amphotericin B tends to delay the increase of parasitemia and significantly delays host death plasmodium berghei-infected mice.
安全信息
毒性 | spm-rbt-ivn 20 mg/kg/11D JRPFA4 7,13,64 |
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