L-165041
| 中文名称 | L-165041 |
|---|---|
| 中文同义词 | [4-[3-(4-乙酰基-3-羟基-2-丙基苯氧基)丙氧基]苯氧基]乙酸;L-165,041 CALBIOCHEM;2-(4-(3-(4-乙酰基-3-羟基-2-丙基苯氧基)丙氧基)苯氧基)乙酸 |
| 英文名称 | L-165,041 |
| 英文同义词 | L-165041, >=98%;2-[4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]-;2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy)phenoxy)acetic acid;Acetic acid, 2-[4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]-;L 1q5041;COMPOUND P;L-165,041;4-[3-(4-ACETYL-3-HYDROXY-2-PROPYLPHENOXY)PROPOXY]PHENOXYACETIC ACID |
| CAS号 | 79558-09-1 |
| 分子式 | C22H26O7 |
| 分子量 | 402.44 |
| EINECS号 | |
| 相关类别 | 细胞生物学;医药中间体;Intracellular receptor;API |
| Mol文件 | 79558-09-1.mol |
| 结构式 |  |
L-165041 性质
| 熔点 | 127-128 °C(lit.) |
|---|---|
| 沸点 | 600.8±55.0 °C(Predicted) |
| 密度 | 1.222±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：>10 mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 3.23±0.10(Predicted) |
| 颜色 | 米白色 |
| 稳定性 | 感光 |
|
PPARδ 6 nM (Ki) |
PPARγ 730 nM (Ki) |
L-165041 is a PPARδ agonist, with K i s of 6 nM and appr 730 nM for PPARδ and PPARγ, respectively. L-165041 (1 or 5 µM) inhibits VEGF-induced endothelial cells (ECs) proliferation and migration. L-165041 negatively affects cell cycle progression in VEGF-activated human umbilical vein ECs (HUVECs). L-165041 (10 µM)inhibits PPARδ-independent, VEGF-induced angiogenesis. PPARδ ligand L-165041 inhibits PDGF-induced rVSMC proliferation and migration. With 1 h of L-165041 pretreatment, PDGF-induced cellular migration is inhibited. L-165041 (10 μM) significantly suppresses S phase transition induced by PDGF.
L-165041 (5 mg/kg/day, i.p.) significantly lowers the formation of lipid droplets in mice. L-165041 markedly reduces the level of both the hepatic cholesterol and triglycerides in mice. L-165041 increases mRNA expression levels of PPARδ compared to the vehicle group. Lipoprotein lipase (LPL) expression in L-165041-treated mice is significantly higher than that in the vehicle group.
安全信息
| WGK Germany | 3 |
|---|
| 提供商 | 语言 |
|---|---|
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-20019 | L-165041 L-165041 | 79558-09-1 | 10mM * 1mLin DMSO | 664元 |
| 2024/04/30 | HY-20019 | L-165041 L-165041 | 79558-09-1 | 10mg | 884元 |