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| | NCGC607 Basic information |
| Product Name: | NCGC607 | | Synonyms: | NCGC607;inhibit,Glucosidase,NCGC-607,NCGC 607,Inhibitor;Benzamide, 2-[2-[(4-iodophenyl)amino]-2-oxoethoxy]-N-[2-(methylphenylamino)-2-oxoethyl]-;2-[(2-{[(4-iodophenyl)carbamoyl]methoxy}phenyl)formamido]-N-methyl-N-phenylacetamide | | CAS: | 1462267-07-7 | | MF: | C24H22IN3O4 | | MW: | 543.35 | | EINECS: | | | Product Categories: | | | Mol File: | 1462267-07-7.mol |  |
| | NCGC607 Chemical Properties |
| Boiling point | 734.5±60.0 °C(Predicted) | | density | 1.555±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml; DMSO: 25 mg/ml | | form | A crystalline solid | | pka | 12.44±0.70(Predicted) | | color | White to off-white |
| | NCGC607 Usage And Synthesis |
| Description | NCGC607 is a salicylic acid derivative and small molecule glucocerebrosidase (GCase) chaperone. A mutation in the GCase gene is found in patients with Gaucher disease and is the most common genetic risk factor for Parkinson’s disease. In induced pluripotent stem cell-derived (iPSC) macrophages from patients with Gaucher disease, NCGC607 (3 μM) restores protein levels of GCase, translocates it to the lysosome, and decreases lysosomal levels of the glycolipid glucosylceramide. In iPSC-derived cells differentiated into dopamine neurons (iDA), NCGC607 increases GCase activity and translocation to the lysosome, where it decreases glucosylceramide as well as glucosylsphingosine levels. It also rescues decreased α-synuclein levels in iDA neurons. | | Uses | 2-[2-[(4-Iodophenyl)amino]-2-oxoethoxy]-N-[2-(methylphenylamino)-2-oxoethyl]-benzamide is derived from 4-Iodoaniline (I686800), which is a iodine substituted aniline that is widely used as chemical intermediates in the manufacturing of pesticides, dyes and drugs. 4-Iodoaniline was shown to be a more potent nephrotoxicant in vitro than other anilines. |
| | NCGC607 Preparation Products And Raw materials |
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